Kataoka Masahiro, Hirano Yasumitsu, Ishii Toshimasa, Ishikawa Shintaro, Kataoka Atsuko, Fujii Takatsugu, Shimamura Satoshi
Department of Gastrointestinal Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
Cancer Diagn Progn. 2021 Nov 3;1(5):479-484. doi: 10.21873/cdp.10064. eCollection 2021 Nov-Dec.
BACKGROUND/AIM: The geriatric nutrition risk index (GNRI) is a presumptive prognosticator in a variety of carcinomas. We investigated whether it similarly predicts outcomes of elderly patients with colorectal cancer (CRC).
A total of 904 older adults (≥65 years) undergoing radical resections of CRC between April 2011 and December 2015 proved eligible for study. Each was grouped by preoperative status (cut-off point, 98) as low-level or normal GNRI, using propensity score matching to compare rates of complications, disease-free survival (DFS), and overall survival (OS).
After matching (n=127, each group), those with low-level (vs. normal) GNRI values experienced significantly more complications (p=0.001), and 5-year survival was significantly poorer (DFS: p=0.006; OS: p=0.002).
In elderly patients with resected CRC, preoperative GNRI may have significant prognostic merit.
背景/目的：老年营养风险指数（GNRI）是多种癌症的一种推测性预后指标。我们研究了它是否同样能预测老年结直肠癌（CRC）患者的预后。
2011年4月至2015年12月期间，共有904名接受CRC根治性切除术的老年人（≥65岁）符合研究条件。根据术前状态（临界值为98）将每位患者分为低水平或正常GNRI组，采用倾向评分匹配法比较并发症发生率、无病生存率（DFS）和总生存率（OS）。
匹配后（每组n = 127），GNRI值低水平（与正常水平相比）的患者并发症明显更多（p = 0.001），5年生存率明显更低（DFS：p = 0.006；OS：p = 0.002）。
在接受CRC切除术的老年患者中，术前GNRI可能具有显著的预后价值。
