神经炎症 PET 成像：现状与未来方向。
Neuroinflammation PET Imaging: Current Opinion and Future Directions.
机构信息
Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California.
Department of Bioengineering, Stanford University, Stanford, California; and.
出版信息
J Nucl Med. 2020 Aug;61(8):1107-1112. doi: 10.2967/jnumed.119.229443. Epub 2020 Jul 3.
Abstract
Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however, its exact role in vivo is yet to be fully understood. PET imaging enables investigation, quantification, and tracking of different neuroinflammation biomarkers in living subjects longitudinally. One such biomarker that has been imaged extensively using PET is translocator protein 18 kDa (TSPO). Although imaging TSPO has yielded valuable clinical data linking neuroinflammation to various neurodegenerative diseases, considerable limitations of TSPO PET have prompted identification of other more cell-specific and functionally relevant biomarkers. This review analyzes the clinical potential of available and emerging PET biomarkers of innate and adaptive immune responses, with mention of exciting future directions for the field.
摘要
神经炎症是许多神经疾病的关键病理标志，但其在体内的确切作用仍有待充分了解。PET 成像使我们能够在活体中对不同的神经炎症生物标志物进行研究、定量和跟踪。其中一种广泛使用 PET 成像的生物标志物是 18 kDa 转位蛋白（TSPO）。尽管成像 TSPO 已经产生了有价值的临床数据，将神经炎症与各种神经退行性疾病联系起来，但 TSPO PET 的相当多局限性促使人们确定了其他更具细胞特异性和功能相关性的生物标志物。这篇综述分析了现有和新兴的先天和适应性免疫反应的 PET 生物标志物的临床潜力，并提到了该领域令人兴奋的未来方向。
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