小鼠部分脑质子照射后小胶质细胞的细胞特异性分析
Cell-specific analysis of microglia following partial brain proton irradiation in mice.
作者信息
Nexhipi Sindi, Suckert Theresa, Soltwedel Johannes, Beyreuther Elke, Noßol Max, Pecht Laura, Boucsein Marc, Schneider Moritz, Horst Felix, Löck Steffen, Krause Mechthild, Lühr Armin, Dietrich Antje
机构信息
OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany.
German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
出版信息
Clin Transl Radiat Oncol. 2025 Jun 27;54:101003. doi: 10.1016/j.ctro.2025.101003. eCollection 2025 Sep.
• Inflammatory response is evaluated via microglia density, location and activation. • Microglia parameters are shown for whole mouse brain slices co-registered with dose. • Microglia density increases in accordance with the contrast-enhanced volume. • Microglia density increase is mainly attributed to the radiated region. • Periventricular and high dose areas show increased microglia activation and proliferation.
• 通过小胶质细胞密度、位置和激活来评估炎症反应。
• 显示了与剂量共同配准的全脑小鼠脑片的小胶质细胞参数。
• 小胶质细胞密度随对比增强体积增加。
• 小胶质细胞密度增加主要归因于辐射区域。
• 脑室周围和高剂量区域显示小胶质细胞激活和增殖增加。
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