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小鼠部分脑质子照射后小胶质细胞的细胞特异性分析

Cell-specific analysis of microglia following partial brain proton irradiation in mice.

作者信息

Nexhipi Sindi, Suckert Theresa, Soltwedel Johannes, Beyreuther Elke, Noßol Max, Pecht Laura, Boucsein Marc, Schneider Moritz, Horst Felix, Löck Steffen, Krause Mechthild, Lühr Armin, Dietrich Antje

机构信息

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany.

German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

出版信息

Clin Transl Radiat Oncol. 2025 Jun 27;54:101003. doi: 10.1016/j.ctro.2025.101003. eCollection 2025 Sep.

DOI:10.1016/j.ctro.2025.101003
PMID:40687733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12272428/
Abstract

• Inflammatory response is evaluated via microglia density, location and activation. • Microglia parameters are shown for whole mouse brain slices co-registered with dose. • Microglia density increases in accordance with the contrast-enhanced volume. • Microglia density increase is mainly attributed to the radiated region. • Periventricular and high dose areas show increased microglia activation and proliferation.

摘要

• 通过小胶质细胞密度、位置和激活来评估炎症反应。

• 显示了与剂量共同配准的全脑小鼠脑片的小胶质细胞参数。

• 小胶质细胞密度随对比增强体积增加。

• 小胶质细胞密度增加主要归因于辐射区域。

• 脑室周围和高剂量区域显示小胶质细胞激活和增殖增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/9b184bc5ac02/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/1ff88f5f6091/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/5b4c546b3670/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/866e62f4e4df/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/4f2821d48609/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/82b20e3570b3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/9b184bc5ac02/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/1ff88f5f6091/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/5b4c546b3670/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/866e62f4e4df/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/4f2821d48609/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/82b20e3570b3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c46f/12272428/9b184bc5ac02/gr5.jpg

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引用本文的文献

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Radiation-induced changes of reactive astrocyte distribution in mice as a late response to partial-brain proton irradiation.作为对部分脑质子照射的晚期反应，辐射诱导小鼠反应性星形胶质细胞分布的变化。
Acta Oncol. 2025 Jul 23;64:902-908. doi: 10.2340/1651-226X.2025.44056.

本文引用的文献

1
Cranial irradiation disrupts homeostatic microglial dynamic behavior.颅脑照射破坏了小胶质细胞的内稳态动态行为。
J Neuroinflammation. 2024 Apr 3;21(1):82. doi: 10.1186/s12974-024-03073-z.
2
-establishment of small animal proton and photon image-guided radiation experiments.建立小动物质子和光子图像引导放射实验。
Phys Med Biol. 2024 Apr 24;69(9). doi: 10.1088/1361-6560/ad3887.
3
Proton therapy induces a local microglial neuroimmune response.质子治疗会引起局部小胶质细胞神经免疫反应。
Radiother Oncol. 2024 Apr;193:110117. doi: 10.1016/j.radonc.2024.110117. Epub 2024 Mar 6.
4
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets.神经退行性疾病中的小胶质细胞：机制与潜在治疗靶点。
Signal Transduct Target Ther. 2023 Sep 22;8(1):359. doi: 10.1038/s41392-023-01588-0.
5
Microglia and the Blood-Brain Barrier: An External Player in Acute and Chronic Neuroinflammatory Conditions.小胶质细胞与血脑屏障：急性和慢性神经炎症状态下的外部作用者。
Int J Mol Sci. 2023 May 23;24(11):9144. doi: 10.3390/ijms24119144.
6
Radiation-Induced Brain Injury: Age Dependency of Neurocognitive Dysfunction Following Radiotherapy.放射性脑损伤：放疗后神经认知功能障碍的年龄依赖性
Cancers (Basel). 2023 May 31;15(11):2999. doi: 10.3390/cancers15112999.
7
Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease.小胶质细胞：治疗年龄相关性认知衰退和阿尔茨海默病的药理学靶点。
Front Pharmacol. 2023 Feb 9;14:1125982. doi: 10.3389/fphar.2023.1125982. eCollection 2023.
8
Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D.Slice2Volume：融合多模态医学成像和光显微镜数据的辐照损伤脑组织的 3D 图像。
Radiother Oncol. 2023 May;182:109591. doi: 10.1016/j.radonc.2023.109591. Epub 2023 Feb 28.
9
Increased relative biological effectiveness and periventricular radiosensitivity in proton therapy of glioma patients.质子治疗脑胶质瘤患者中相对生物效应增加和脑室周围放射敏感性增加。
Radiother Oncol. 2023 Jan;178:109422. doi: 10.1016/j.radonc.2022.11.011. Epub 2022 Nov 23.
10
Combined proton radiography and irradiation for high-precision preclinical studies in small animals.用于小动物高精度临床前研究的质子射线照相与辐照联用技术
Front Oncol. 2022 Aug 31;12:982417. doi: 10.3389/fonc.2022.982417. eCollection 2022.