School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Department of Clinical Research, Federal University of Uberlândia, Uberlândia, Brazil.
Obes Surg. 2020 Oct;30(10):4046-4060. doi: 10.1007/s11695-020-04807-7.
This systematic review and meta-analysis was performed to investigate the possible changes of FGF-19 and FGF-21 after bariatric surgery (BS). Electronic databases including PubMed and Scopus were systematically searched up to February 2020 to identify pertinent studies. A total of 25 different studies were included. The overall pooled analysis identified that BS caused a significant increase in FGF-19, but had no significant effect on FGF-21. For FGF-19, this finding was supported in the subgroup analyses. For FGF-21, Roux-en-Y gastric bypass (RYGB) surgery significantly increased FGF-21 levels, whereas, in studies with follow-up duration ≥ 1 year, FGF-21 levels decreased significantly. BS reduces circulating concentration of FGF-19, but might increase FGF-21 after RYGB or decrease FGF-21 after ≥ 1 year.
本系统评价和荟萃分析旨在研究减重手术后（BS） FGF-19 和 FGF-21 可能发生的变化。系统检索了 PubMed 和 Scopus 等电子数据库，截至 2020 年 2 月，以确定相关研究。共纳入 25 项不同的研究。总体汇总分析表明，BS 导致 FGF-19 显著增加，但对 FGF-21 没有显著影响。对于 FGF-19，亚组分析支持这一发现。对于 FGF-21，Roux-en-Y 胃旁路术（RYGB）显著增加了 FGF-21 水平，而在随访时间≥1 年的研究中，FGF-21 水平显著下降。BS 降低了循环中 FGF-19 的浓度，但 RYGB 后可能会增加 FGF-21，而≥1 年后则可能会降低 FGF-21。
