Pona Adrian, Quan Eugenie Y, Cline Abigail, Feldman Steven R
Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.
Dermatol Online J. 2020 May 15;26(5):13030/qt79g6z0cf.
To review the use of gentian violet in dermatology.
A comprehensive literature search on gentian violet in dermatology practice was performed through PubMed.
Gentian violet is effective in treating methicillin-resistant Staphylococcus aureus-colonized skin lesions; mean number of days for complete eradication was 9.1 days. Gentian violet is almost as effective as ketoconazole and more effective than nystatin in the treatment of oral thrush in AIDS patients. In an in vitro study on cutaneous T cell lymphoma cell lines, there was no difference between nitrogen mustard and gentian violet in stimulating apoptosis. When comparing gentian violet to silver sulfadiazine dressings in healing burn wounds, the gentian violet treatment group reported less pain, fewer febrile episodes, and decreased bacterial growth compared to control. In atopic dermatitis subjects, gentian violet decreased Staphylococcus aureus colonization and improved disease severity in lesional skin compared to non-lesional skin.
Studies have investigated gentian violet's antibacterial, antifungal, antiviral, antiparasitic, anti-angiogenic, antitumor, and wound healing properties. Gentian violet is a low cost and well-tolerated topical agent with the potential for widespread applications in dermatology.
回顾龙胆紫在皮肤病学中的应用。
通过PubMed对皮肤病学实践中龙胆紫进行全面的文献检索。
龙胆紫在治疗耐甲氧西林金黄色葡萄球菌定植的皮肤病变方面有效；完全清除的平均天数为9.1天。在治疗艾滋病患者的口腔念珠菌病方面，龙胆紫几乎与酮康唑一样有效，且比制霉菌素更有效。在一项关于皮肤T细胞淋巴瘤细胞系的体外研究中，氮芥和龙胆紫在刺激细胞凋亡方面没有差异。在比较龙胆紫与磺胺嘧啶银敷料治疗烧伤创面时，与对照组相比，龙胆紫治疗组疼痛减轻、发热发作减少且细菌生长减少。在特应性皮炎患者中，与非皮损皮肤相比，龙胆紫减少了金黄色葡萄球菌定植并改善了皮损皮肤的疾病严重程度。
研究已经探究了龙胆紫的抗菌、抗真菌、抗病毒、抗寄生虫、抗血管生成、抗肿瘤和伤口愈合特性。龙胆紫是一种低成本且耐受性良好的局部用药，在皮肤病学中有广泛应用的潜力。
