Stiff K M, Glines K R, Muse M E, Cline A, Feldman S R, Jorizzo J L, Huang W W
Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.
Dermatol Online J. 2020 Jan 15;26(1):13030/qt3sm8q75w.
Pyoderma gangrenosum is a rare autoinflammatory skin disease. Treatment is multifactorial, addressing inflammation, pain, underlying disease, if present, and the wound. Gentian violet has been used for hundreds of years in a variety of dermatologic conditions for its anti-inflammatory properties. This study aims to evaluate gentian violet in wound healing for pyoderma gangrenosum. We conducted a retrospective chart review of patients with pyoderma gangrenosum treated with gentian violet at the Wake Forest School of Medicine Department of Dermatology in the last 10 years. The primary outcome was clinical improvement. Of the 34 cases that met inclusion criteria, 70% improved with gentian violet, 24% had no documented change, 3% initially improved then worsened, and 3% had unclear results. Gentian violet is a safe and cheap treatment that may improve resolution of pyoderma gangrenosum lesions in addition to systemic therapy.
坏疽性脓皮病是一种罕见的自身炎症性皮肤病。治疗是多方面的，要解决炎症、疼痛、潜在疾病（如果存在）以及伤口问题。龙胆紫因其抗炎特性，在多种皮肤病中已被使用数百年。本研究旨在评估龙胆紫在坏疽性脓皮病伤口愈合中的作用。我们对过去10年在维克森林医学院皮肤科接受龙胆紫治疗的坏疽性脓皮病患者进行了回顾性病历审查。主要结果是临床改善。在符合纳入标准的34例病例中，70%使用龙胆紫后病情改善，24%无记录变化，3%最初改善后恶化，3%结果不明。除全身治疗外，龙胆紫是一种安全且廉价的治疗方法，可能会改善坏疽性脓皮病皮损的消退情况。
