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Angiotensin-(1-7) and Obesity: Role in Cardiorespiratory Fitness and COVID-19 Implications.血管紧张素 -（1 - 7）与肥胖：对心肺适能的作用及对新冠病毒病的影响
Obesity (Silver Spring). 2020 Oct;28(10):1786. doi: 10.1002/oby.22949. Epub 2020 Sep 1.
2
COVID-19: Critical Role of Angiotensin 1-7 in ACE2 Modulation.新型冠状病毒肺炎：血管紧张素1-7在血管紧张素转换酶2调节中的关键作用
Ann Acad Med Singap. 2020 Jun;49(6):398-400.
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COVID-19: Underlying Adipokine Storm and Angiotensin 1-7 Umbrella.COVID-19：潜在的脂肪因子风暴与血管紧张素 1-7 伞状系统。
Front Immunol. 2020 Jul 21;11:1714. doi: 10.3389/fimmu.2020.01714. eCollection 2020.
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SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis.严重急性呼吸综合征冠状病毒2型发病机制：肾素-血管紧张素系统失衡促进肺纤维化。
Front Cell Infect Microbiol. 2020 Jun 12;10:340. doi: 10.3389/fcimb.2020.00340. eCollection 2020.
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Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS-CoV-2?高心肺适能是否能对感染新型冠状病毒后的促炎反应起到一定的保护作用？
Obesity (Silver Spring). 2020 Aug;28(8):1378-1381. doi: 10.1002/oby.22849. Epub 2020 Jul 9.
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Prehabilitation Telemedicine in Neoadjuvant Surgical Oncology Patients During the Novel COVID-19 Coronavirus Pandemic.新型冠状病毒肺炎大流行期间新辅助外科肿瘤学患者的术前康复远程医疗
Ann Surg. 2020 Aug;272(2):e81-e83. doi: 10.1097/SLA.0000000000004002.
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Should we use angiotensin II infusion in COVID-19-associated vasoplegic shock?我们是否应该在新型冠状病毒肺炎相关的血管麻痹性休克中使用血管紧张素II输注？
Crit Care. 2020 Jul 9;24(1):407. doi: 10.1186/s13054-020-03144-6.
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Potential pathophysiology of COVID-19 in patients with obesity. Comment on Br J Anaesth 2020; 125: e262-e263.肥胖患者感染新型冠状病毒肺炎的潜在病理生理学。对《英国麻醉学杂志》2020年；125卷：e262 - e263的评论
Br J Anaesth. 2020 Sep;125(3):e283-e284. doi: 10.1016/j.bja.2020.05.055. Epub 2020 Jun 7.
10
Countermeasure and therapeutic: A(1-7) to treat acute respiratory distress syndrome due to COVID-19 infection.对策与治疗：A(1 - 7)用于治疗由COVID - 19感染引起的急性呼吸窘迫综合征。
J Renin Angiotensin Aldosterone Syst. 2020 Oct-Dec;21(4):1470320320972018. doi: 10.1177/1470320320972018.

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Potential Physiological and Cellular Mechanisms of Exercise That Decrease the Risk of Severe Complications and Mortality Following SARS-CoV-2 Infection.运动降低SARS-CoV-2感染后严重并发症和死亡率风险的潜在生理和细胞机制
Sports (Basel). 2021 Aug 31;9(9):121. doi: 10.3390/sports9090121.
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A Possible Preventive Role of Physically Active Lifestyle during the SARS-CoV-2 Pandemic; Might Regular Cold-Water Swimming and Exercise Reduce the Symptom Severity of COVID-19?体育锻炼生活方式在 SARS-CoV-2 大流行期间可能具有预防作用；定期冷水游泳和运动是否可以减轻 COVID-19 的症状严重程度？
Int J Environ Res Public Health. 2021 Jul 4;18(13):7158. doi: 10.3390/ijerph18137158.
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Dual role for angiotensin-converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat.血管紧张素转化酶 2 在严重急性呼吸综合征冠状病毒 2 感染和心脏脂肪中的双重作用。
Obes Rev. 2021 May;22(5):e13225. doi: 10.1111/obr.13225. Epub 2021 Mar 3.

本文引用的文献

1
Activation of Ang-(1-7)/Mas Receptor Is a Possible Strategy to Treat Coronavirus (SARS-CoV-2) Infection.激活血管紧张素-(1-7)/Mas受体是治疗冠状病毒（SARS-CoV-2）感染的一种可能策略。
Front Physiol. 2020 Jun 19;11:730. doi: 10.3389/fphys.2020.00730. eCollection 2020.
2
Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS-CoV-2?高心肺适能是否能对感染新型冠状病毒后的促炎反应起到一定的保护作用？
Obesity (Silver Spring). 2020 Aug;28(8):1378-1381. doi: 10.1002/oby.22849. Epub 2020 Jul 9.
3
Substituting Angiotensin-(1-7) to Prevent Lung Damage in SARS-CoV-2 Infection?用血管紧张素-（1-7）替代以预防新型冠状病毒感染中的肺损伤？
Circulation. 2020 May 26;141(21):1665-1666. doi: 10.1161/CIRCULATIONAHA.120.047297. Epub 2020 Apr 3.
4
Angiotensin-(1-7), Adipokines and Inflammation.血管紧张素-(1-7)、脂肪因子与炎症。
Metabolism. 2019 Jun;95:36-45. doi: 10.1016/j.metabol.2019.03.006. Epub 2019 Mar 21.
5
Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm.肥胖与青少年期早产儿的高血压和血管紧张素 II 水平升高有关，但血管紧张素-(1-7)水平降低。
J Pediatr. 2019 Feb;205:55-60.e1. doi: 10.1016/j.jpeds.2018.09.058. Epub 2018 Nov 5.
6
The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7).肾素-血管紧张素系统的 ACE2/血管紧张素-(1-7)/MAS 轴：关注血管紧张素-(1-7)。
Physiol Rev. 2018 Jan 1;98(1):505-553. doi: 10.1152/physrev.00023.2016.
7
Favorable Vascular Actions of Angiotensin-(1-7) in Human Obesity.血管紧张素-(1-7)在人类肥胖中的有利作用。
Hypertension. 2018 Jan;71(1):185-191. doi: 10.1161/HYPERTENSIONAHA.117.10280. Epub 2017 Dec 4.
8
Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise.血管紧张素转换酶2缺乏对身体机能以及心脏和骨骼肌运动生理适应性的影响。
Hypertens Res. 2016 Jul;39(7):506-12. doi: 10.1038/hr.2016.28. Epub 2016 Apr 7.
9
Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism.内毒素诱导的骨骼肌消耗通过血管紧张素-(1-7)通过 p38 MAPK 依赖的机制来预防。
Clin Sci (Lond). 2015 Sep;129(6):461-76. doi: 10.1042/CS20140840. Epub 2015 May 19.
10
Oral Angiotensin-(1-7) prevented obesity and hepatic inflammation by inhibition of resistin/TLR4/MAPK/NF-κB in rats fed with high-fat diet.口服血管紧张素-(1-7)通过抑制高脂肪饮食喂养大鼠的抵抗素/TLR4/MAPK/NF-κB 预防肥胖和肝炎症。
Peptides. 2013 Aug;46:47-52. doi: 10.1016/j.peptides.2013.05.010. Epub 2013 May 25.

Angiotensin-(1-7) and Obesity: Role in Cardiorespiratory Fitness and COVID-19 Implications.

作者信息

Motta-Santos Daisy, Santos Robson A S, Santos Sérgio Henrique Sousa

机构信息

Sports Department, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

INCT NanoBiofar, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

出版信息

Obesity (Silver Spring). 2020 Oct;28(10):1786. doi: 10.1002/oby.22949. Epub 2020 Sep 1.

DOI:10.1002/oby.22949
PMID:32621779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7362166/
Abstract
摘要