Institute of Human Nutrition and Dietetics, Poznań University of Life Sciences, Wojska Polskiego 31, 60-624 Poznań, Poland.
Institute of Food Technology of Plant Origin, Poznań University of Life Sciences, 60-634 Poznań, Poland.
Prostaglandins Leukot Essent Fatty Acids. 2020 Aug;159:102155. doi: 10.1016/j.plefa.2020.102155. Epub 2020 Jun 27.
The aim of this study was to compare fatty acid (FA) intake and status in postmenopausal women with or without metabolic syndrome (MetS). 131 women were recruited to a case-control study in 2016-2018 in Poznań, Poland. Dietary intake, anthropometric and biochemical measurements, FA level in red blood cells (RBCs), and FADS1 (rs174546) and FADS2 (rs3834458) genotypes were determined. Compared to women without MetS, those with MetS had lower levels of EPA, n-3, EPA/α-linolenic acid (ALA), EPA/AA, DHA/AA, EPA+DHA/AA, PUFA/saturated FA, PUFA/monounsaturated FA, and n-3/n-6 ratios in RBCs. Participants with at least one minor allele of each polymorphism had lower levels of EPA, and EPA/AA, and a higher level of DHA/EPA in RBCs than did women with major alleles. MetS is associated with lower levels FAs that have a protective effect on cardiometabolic health. FADS1 and FADS2 polymorphisms are associated with unfavorable FA and status EPA/AA in RBC contributes to MetS.
本研究旨在比较患有或不患有代谢综合征（MetS）的绝经后妇女的脂肪酸（FA）摄入和状况。2016 年至 2018 年，在波兰波兹南招募了 131 名妇女进行病例对照研究。测定了膳食摄入量、人体测量学和生化测量值、红细胞（RBC）中的 FA 水平以及 FADS1（rs174546）和 FADS2（rs3834458）基因型。与没有 MetS 的妇女相比，患有 MetS 的妇女 RBC 中的 EPA、n-3、EPA/α-亚麻酸（ALA）、EPA/AA、DHA/AA、EPA+DHA/AA、多不饱和脂肪酸/饱和脂肪酸、多不饱和脂肪酸/单不饱和脂肪酸和 n-3/n-6 比例较低。每种多态性至少有一种次要等位基因的参与者的 EPA 和 EPA/AA 水平较低，而 RBC 中的 DHA/EPA 水平较高。MetS 与对心脏代谢健康具有保护作用的较低水平 FA 相关。FADS1 和 FADS2 多态性与不利的 FA 相关，并且 RBC 中 EPA/AA 的状态有助于 MetS。
