Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Urol Oncol. 2020 Dec;38(12):918-928. doi: 10.1016/j.urolonc.2020.06.003. Epub 2020 Jul 1.
Prostate cancer (CaP) is a leading cause of cancer deaths in the worldwide with broad range of clinical manifestations ranging from relatively indolent to aggressive metastasis. Altered expression of many circulating long non-coding RNAs (lncRNAs), known to have role in tumorigenesis and metastasis, have already been reported in CaP patients. These lncRNAs modulate CaP pathogenesis by modulating multiple genes and thus altering metabolic pathways. Sustained androgen receptor (AR) signaling is one such key feature of castration-resistant prostate cancer, a CaP stage that has unmet need of accurate diagnostic and prognostic tools, that is affected by lncRNAs. In this review, we have discussed the emerging functions and associations of AR lncRNAs in CaP and highlighted their potential implications in cancer diagnostics and therapeutics. Further, extensive literature analysis in this article indicates that there is an immediate unmet need in the translational approach toward the hitherto identified AR lncRNAs. The characterization of AR lncRNAs involved in CaP is not exhaustive and adequate validation studies are still required to corroborate the present results that would be the impending future of basic research setting into clinical practice.
前列腺癌（CaP）是全球癌症死亡的主要原因，其临床表现广泛，从相对惰性到侵袭性转移不等。已经有报道称，许多循环长非编码 RNA（lncRNA）的表达发生改变，这些 lncRNA 已知在肿瘤发生和转移中起作用。这些 lncRNA 通过调节多个基因从而改变代谢途径来调节 CaP 的发病机制。持续的雄激素受体（AR）信号是去势抵抗性前列腺癌（一种 CaP 阶段）的一个关键特征，该阶段缺乏准确的诊断和预后工具，受 lncRNA 影响。在这篇综述中，我们讨论了 AR lncRNA 在 CaP 中的新兴功能和关联，并强调了它们在癌症诊断和治疗中的潜在意义。此外，本文对大量文献进行了分析，表明在目前已鉴定的 AR lncRNA 的转化方法方面存在迫切的未满足需求。涉及 CaP 的 AR lncRNA 的特征尚未详尽无遗，仍需要进行充分的验证研究来证实目前的结果，这将是基础研究迈向临床实践的未来趋势。
