Misawa Aya, Takayama Ken-Ichi, Inoue Satoshi
Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Cancer Sci. 2017 Nov;108(11):2107-2114. doi: 10.1111/cas.13352. Epub 2017 Sep 5.
Long non-coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins the aberrant expression of which has been documented in various types of cancer, including prostate cancer. Lack of appropriate sensitive and specific biomarkers for prostate cancer has led to overdiagnosis and overtreatment, making lncRNAs promising novel biomarkers as well as therapeutic targets for the disease. The present review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer, which contribute to carcinogenesis. In particular, we focused on lncRNAs regulated by androgen receptor and expressed in castration-resistant prostate cancer.
长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸的RNA转录本，它们不编码蛋白质，其异常表达已在包括前列腺癌在内的多种癌症中得到证实。前列腺癌缺乏合适的敏感且特异的生物标志物导致了过度诊断和过度治疗，这使得lncRNAs有望成为该疾病新的生物标志物和治疗靶点。本综述试图总结目前关于lncRNA在前列腺癌中的表达模式及机制的知识，这些知识有助于了解前列腺癌的致癌过程。特别地，我们聚焦于受雄激素受体调控并在去势抵抗性前列腺癌中表达的lncRNAs。
