Florida Hospital, Orlando, FL, USA.
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Pulmonology. 2021 May-Jun;27(3):215-218. doi: 10.1016/j.pulmoe.2020.06.006. Epub 2020 Jul 1.
The present study investigated the relationship between central hemodynamics and lung function and the response to an acute bout of exercise in COPD.
Based on the severity of COPD, moderate group (MOD, n = 12) and more mild group (MLD, n = 12) underwent central hemodynamic assessments pre- and post-peak exercise.
In the entire cohort (n = 24), central diastolic blood pressure (cDBP) was associated with pulmonary function. Post-exercise, cDBP remained elevated (p < 0.01), however, peripheral diastolic blood pressure (pDBP) was reduced (p = 0.02). Prior to exercise, the MOD showed higher cDBP and heart rate (HR) than the MLD (p = 0.02 and p = 0.01, respectively), but no difference in central aortic/arterial stiffness (p > 0.05). These findings remained similar post-exercise.
Central diastolic blood pressure is linked to pulmonary function in COPD and it is elevated after exercise-induced reductions in pDBP. Central diastolic blood pressure is higher in the MOD than the MLD, however, there was no difference in central aortic/arterial stiffness between groups.
本研究旨在探讨 COPD 患者中心血流动力学与肺功能的关系，以及其对急性运动的反应。
根据 COPD 的严重程度，将中度组（MOD，n=12）和更轻度组（MLD，n=12）分别在运动峰值前后进行中心血流动力学评估。
在整个队列（n=24）中，中心舒张压（cDBP）与肺功能相关。运动后，cDBP 仍升高（p<0.01），而外周舒张压（pDBP）降低（p=0.02）。运动前，MOD 的 cDBP 和心率（HR）高于 MLD（p=0.02 和 p=0.01），但中心主动脉/动脉僵硬度无差异（p>0.05）。这些发现运动后仍然相似。
在 COPD 中，中心舒张压与肺功能相关，并且在 pDBP 运动诱导降低后升高。MOD 的中心舒张压高于 MLD，但两组之间的中心主动脉/动脉僵硬度无差异。
