Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Cardiology, King George's Medical University, Lucknow, India.
Physiol Rep. 2024 Sep;12(17):e16109. doi: 10.14814/phy2.16109.
As the pulmonary system and cardiovascular system are intimately linked, patients with chronic obstructive pulmonary disease (COPD) and asthma have high risk for developing cardiovascular diseases (CVDs) and altered central hemodynamic.
We aim to assess the central aortic blood pressure (CABP) indices, pulse wave velocity (PWV) and other indicators of arterial stiffness in Indian patients with COPD and bronchial asthma.
This is a single-center, cross-sectional study conducted in outpatients diagnosed with either chronic stable phase of COPD or bronchial asthma. CABP indices, vascular age, arterial stiffness and central hemodynamics were measured in patients.
Of 193 patients with obstructive airway disease who were enrolled, (n = 81 had COPD and n = 112 had partially-controlled bronchial asthma) the proportion of male patients was higher in both groups. The PWV, augmentation index (AI) and vascular age (VA) were significantly higher in patients with COPD compared to those with bronchial asthma (all, p < 0.05).
The study showed that PWV, AI and VA were higher in patients with stable COPD without any cardiac comorbidities compared to bronchial asthma.
由于肺部系统和心血管系统密切相关，患有慢性阻塞性肺疾病（COPD）和哮喘的患者发生心血管疾病（CVD）和中心血液动力学改变的风险较高。
我们旨在评估印度 COPD 和支气管哮喘患者的中心主动脉血压（CABP）指数、脉搏波速度（PWV）和动脉僵硬度的其他指标。
这是一项在门诊中进行的单中心、横断面研究，诊断为 COPD 慢性稳定期或支气管哮喘。测量患者的 CABP 指数、血管年龄、动脉僵硬度和中心血液动力学。
在纳入的 193 名患有气道阻塞性疾病的患者中（n=81 例患有 COPD，n=112 例患有部分控制的支气管哮喘），两组中男性患者的比例均较高。与支气管哮喘患者相比，COPD 患者的 PWV、增强指数（AI）和血管年龄（VA）显著更高（均 p<0.05）。
该研究表明，与支气管哮喘相比，无任何心脏合并症的稳定型 COPD 患者的 PWV、AI 和 VA 更高。
