转化生长因子-β对Nb2 T淋巴瘤细胞生长的抑制作用
Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-beta.
作者信息
Rayhel E J, Prentice D A, Tabor P S, Flurkey W H, Geib R W, Laherty R F, Schnitzer S B, Chen R, Hughes J P
机构信息
Department of Life Sciences, Indiana State University, Terre Haute.
出版信息
Biochem J. 1988 Jul 1;253(1):295-8. doi: 10.1042/bj2530295.
Abstract
Transforming growth factor-beta (TGF-beta) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-beta exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-beta on Nb2 cell proliferation.
摘要
转化生长因子-β（TGF-β）可抑制大鼠T淋巴瘤Nb2细胞对催乳素和白细胞介素-2的增殖反应。前列腺素可能在TGF-β发挥其抑制作用的途径中起重要作用，因为前列腺素E2也可抑制Nb2细胞的增殖，而前列腺素合成抑制剂吲哚美辛可逆转TGF-β对Nb2细胞增殖的抑制作用。
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本文引用的文献
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J Clin Endocrinol Metab. 1980 Nov;51(5):1058-63. doi: 10.1210/jcem-51-5-1058.
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Thymic origin of the prolactin-dependent Nb2 lymphoma cell line.泌乳素依赖的Nb2淋巴瘤细胞系的胸腺起源
Cancer Res. 1982 Aug;42(8):3138-41.
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Cell Immunol. 1981 Jun;61(1):52-61. doi: 10.1016/0008-8749(81)90353-1.
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