Sporn M B, Roberts A B, Wakefield L M, Assoian R K
Science. 1986 Aug 1;233(4763):532-4. doi: 10.1126/science.3487831.
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.
转化生长因子-β（TGF-β）是一种多功能肽，可控制多种细胞类型的增殖、分化及其他功能。许多细胞可合成TGF-β，且基本上所有细胞都有该肽的特异性受体。TGF-β调节许多其他肽类生长因子的作用，并决定其作用的正负方向。其在体内显著增强结缔组织形成的能力提示了几种治疗应用。
