Yamamoto K, Suzuki Y, Sinohara H
Department of Biochemistry, Kinki University School of Medicine, Osaka, Japan.
Biochem Int. 1988 May;16(5):921-8.
In mice bearing ascites tumors, such as Ehrlich, L1210, Meth-A, and P-815, the plasma levels of contrapsin and alpha-1-antiproteinase remained virtually unchanged. However, the total body pools of these proteins as well as their hepatic mRNA levels increased severalfold, and isoelectrofocusing patterns of these proteins shifted to the lower pH side. Under the same conditions, plasma albumin level decreased by 25%, but its total body pool and hepatic mRNA level increased severalfold. On the other hand, induction of acute phase reaction by injection of bacterial lipopolysaccharide caused differential effects on the two proteinase inhibitors: hepatic translatable mRNA for contrapsin was doubled while that for alpha-1-antiproteinase remained unchanged.
在患有腹水瘤（如艾氏腹水瘤、L1210、Meth - A和P - 815）的小鼠中，抗胰蛋白酶和α1 - 抗蛋白酶的血浆水平几乎保持不变。然而，这些蛋白质的全身总量及其肝脏mRNA水平增加了几倍，并且这些蛋白质的等电聚焦图谱向较低pH侧移动。在相同条件下，血浆白蛋白水平下降了25%，但其全身总量和肝脏mRNA水平增加了几倍。另一方面，注射细菌脂多糖诱导急性期反应对这两种蛋白酶抑制剂产生了不同的影响：抗胰蛋白酶的肝脏可翻译mRNA增加了一倍，而α1 - 抗蛋白酶的肝脏可翻译mRNA保持不变。
