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1
B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens.黑色素瘤患者和正常个体的B淋巴细胞不仅会与黑色素瘤细胞发生反应，还会与无关抗原发生反应。
Br J Cancer. 1988 Aug;58(2):182-5. doi: 10.1038/bjc.1988.188.
2
Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens.钥孔戚血蓝蛋白（KLH）与曼氏血吸虫血清学诊断虫卵抗原之间的高碘酸盐敏感性免疫交叉反应性。
Parasitology. 1999 Jan;118 ( Pt 1):83-9. doi: 10.1017/s0031182098003461.
3
Monoclonal antibodies to human primary uveal melanomas demonstrate tumor heterogeneity.针对人类原发性葡萄膜黑色素瘤的单克隆抗体显示出肿瘤异质性。
Invest Ophthalmol Vis Sci. 1986 Sep;27(9):1362-7.
4
Spontaneous cellular and humoral tumor antigen responses in patients with uveal melanoma.
Melanoma Res. 2015 Dec;25(6):510-8. doi: 10.1097/CMR.0000000000000207.
5
Monoclonal antibodies to uveal melanoma.针对葡萄膜黑色素瘤的单克隆抗体。
Eye (Lond). 1987;1 ( Pt 6):686-90. doi: 10.1038/eye.1987.112.
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Human IgG and IgM monoclonal antibodies against autologous melanoma produced by Epstein-Barr-virus-transformed B lymphocytes.由爱泼斯坦-巴尔病毒转化的B淋巴细胞产生的针对自体黑色素瘤的人IgG和IgM单克隆抗体。
Cancer Immunol Immunother. 1990;32(4):228-34. doi: 10.1007/BF01741705.
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Identification and characterization of keyhole limpet hemocyanin N-glycans mediating cross-reactivity with Schistosoma mansoni.介导与曼氏血吸虫交叉反应的钥孔戚血蓝蛋白N-聚糖的鉴定与表征
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Eur J Immunol. 1991 Feb;21(2):377-83. doi: 10.1002/eji.1830210219.

本文引用的文献

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Serological survey of normal humans for natural antibody to cell surface antigens of melanoma.对正常人进行黑色素瘤细胞表面抗原天然抗体的血清学调查。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4260-4. doi: 10.1073/pnas.77.7.4260.
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Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.用人单克隆抗体检测细胞表面和细胞内抗原。源自恶性黑色素瘤患者淋巴细胞的杂交细胞系。
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Antigenic heterogeneity of surgically removed primary and autologous metastatic human melanoma lesions.手术切除的原发性和自体转移性人类黑色素瘤病变的抗原异质性
J Immunol. 1983 Mar;130(3):1462-6.
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Generation of human monoclonal antibodies reactive with cellular antigens.可与细胞抗原发生反应的人单克隆抗体的产生。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):2026-30. doi: 10.1073/pnas.80.7.2026.
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Tumor heterogeneity.肿瘤异质性
Cancer Res. 1984 Jun;44(6):2259-65.
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Efficient generation in vitro, from human peripheral blood cells, of monoclonal Epstein-Barr virus transformants producing specific antibody to a variety of antigens without prior deliberate immunization.无需事先特意免疫，就能从人外周血细胞高效体外生成产生针对多种抗原的特异性抗体的单克隆爱泼斯坦-巴尔病毒转化体。
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Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein-Barr virus-induced B-cell lines.环孢菌素A促进爱泼斯坦-巴尔病毒诱导的B细胞系在体外的自发生长。
Nature. 1981 Jan 22;289(5795):300-1. doi: 10.1038/289300a0.
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Intratumor immunologic heterogeneity.肿瘤内免疫异质性。
Cancer Metastasis Rev. 1982;1(4):319-34. doi: 10.1007/BF00124215.
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The local excision of choroidal melanomata.
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Release of infectious Epstein-Barr virus by transformed marmoset leukocytes.转化的狨猴白细胞释放传染性爱泼斯坦-巴尔病毒。
Proc Natl Acad Sci U S A. 1973 Jan;70(1):190-4. doi: 10.1073/pnas.70.1.190.

黑色素瘤患者和正常个体的B淋巴细胞不仅会与黑色素瘤细胞发生反应，还会与无关抗原发生反应。

B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens.

作者信息

Damato B E, Campbell A M, McGuire B J, Lee W R, Foulds W S

机构信息

Tennent Institute of Ophthalmology, University of Glasgow, Scotland, UK.

出版信息

Br J Cancer. 1988 Aug;58(2):182-5. doi: 10.1038/bjc.1988.188.

DOI:10.1038/bjc.1988.188
PMID:3262365
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2246765/
Abstract

Peripheral B-lymphocytes of 13 patients with uveal melanoma and of 5 healthy individuals were transformed with Epstein-Barr virus (EBV). The reactivity of these transformed cells with autologous or allogeneic melanoma cells and lymphocytes was measured by the enzyme-linked immunosorbent assay (ELISA). Antigens which are neither self nor common environmental antigens (i.e., plant protoplasts, schistosome antigen and keyhole limpet haemocyanin) were used for controls. Lymphocyte reactivity with all types of antigen was apparent both in patients with uveal melanoma and in normal controls. The response detected by the techniques available is likely to reflect antibody multispecificity leading to mis-identification of irrelevant antigens.

摘要

用爱泼斯坦 - 巴尔病毒（EBV）转化了13例葡萄膜黑色素瘤患者和5名健康个体的外周B淋巴细胞。通过酶联免疫吸附测定（ELISA）测量这些转化细胞与自体或同种异体黑色素瘤细胞及淋巴细胞的反应性。使用既不是自身抗原也不是常见环境抗原的抗原（即植物原生质体、血吸虫抗原和钥孔血蓝蛋白）作为对照。葡萄膜黑色素瘤患者和正常对照中淋巴细胞对所有类型抗原的反应均很明显。现有技术检测到的反应可能反映了抗体的多特异性，从而导致对无关抗原的错误识别。