蛋白聚糖和蛋白聚糖基质小肽在癌症进展、炎症和免疫中的作用。
Versican and Versican-matrikines in Cancer Progression, Inflammation, and Immunity.
机构信息
Division of Blood and Marrow Transplantation, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA.
Cellular & Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, WI.
出版信息
J Histochem Cytochem. 2020 Dec;68(12):871-885. doi: 10.1369/0022155420937098. Epub 2020 Jul 6.
Abstract
Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer development, ranging from proliferative signaling, evasion of growth-suppressor pathways, regulation of cell death, promotion of neoangiogenesis, and tissue invasion and metastasis. Multiple lines of evidence implicate versican and its bioactive proteolytic fragments (matrikines) in the regulation of cancer inflammation and antitumor immune responses. The understanding of the dynamics of versican deposition/accumulation and its proteolytic turnover holds potential for the development of novel immune biomarkers as well as approaches to reset the immune thermostat of tumors, thus promoting efficacy of modern immunotherapies. This article summarizes work from several laboratories, including ours, on the role of this central matrix proteoglycan in tumor progression as well as tumor-immune cell cross-talk.
摘要
Versican 是一种细胞外基质蛋白聚糖，在癌症发展的多个方面发挥关键作用，包括增殖信号、逃避生长抑制途径、调节细胞死亡、促进新血管生成以及组织侵袭和转移。多条证据表明 versican 及其生物活性蛋白水解片段（基质细胞衍生因子）参与了癌症炎症和抗肿瘤免疫反应的调节。versican 沉积/积累及其蛋白水解周转率的动态变化为开发新型免疫生物标志物以及重置肿瘤免疫恒温器从而促进现代免疫疗法的疗效提供了可能。本文总结了包括我们实验室在内的多个实验室的工作，这些工作涉及这种核心基质蛋白聚糖在肿瘤进展以及肿瘤免疫细胞相互作用中的作用。
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