Naegeli Hanspeter, Birch Andrew Nicholas, Casacuberta Josep, De Schrijver Adinda, Gralak Mikołaj Antoni, Guerche Philippe, Jones Huw, Manachini Barbara, Messéan Antoine, Nielsen Elsa Ebbesen, Nogué Fabien, Robaglia Christophe, Rostoks Nils, Sweet Jeremy, Tebbe Christoph, Visioli Francesco, Wal Jean-Michel, Broll Hermann, Gennaro Andrea, Neri Franco Maria, Paraskevopoulos Konstantinos
EFSA J. 2018 Apr 20;16(4):e05213. doi: 10.2903/j.efsa.2018.5213. eCollection 2018 Apr.
The three-event stack cotton GHB614 × LLCotton25 × MON 15985 was produced by conventional crossing to combine three single cotton events, GHB614, LLCotton25 and MON 15985. The EFSA GMO Panel previously assessed the three single events and did not identify safety concerns. No new data on the single events that could lead to modification of the original conclusions on their safety were identified. Based on the molecular, agronomic, phenotypic and compositional characteristics, the combination of the single events and of the newly expressed proteins in the three-event stack cotton did not give rise to food and feed safety or nutritional issues. Food and feed derived from cotton GHB614 × LLCotton25 × MON 15985 are expected to have the same nutritional impact as those derived from the non-GM comparator. In the case of accidental release of viable GHB614 × LLCotton25 × MON 15985 cottonseeds into the environment, this three-event stack cotton would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of cotton GHB614 × LLCotton25 × MON 15985. In conclusion, the GMO Panel considers that cotton GHB614 × LLCotton25 × MON 15985, as described in this application, is as safe as the non-GM comparator with respect to potential effects on human and animal health and the environment.
三性状叠加棉花GHB614×LLCotton25×MON 15985是通过常规杂交培育而成，将三个单性状棉花事件GHB614、LLCotton25和MON 15985进行了组合。欧洲食品安全局转基因生物小组此前已对这三个单性状事件进行了评估，未发现安全问题。未发现可能导致改变其安全性原始结论的单性状事件新数据。基于分子、农艺、表型和成分特征，三性状叠加棉花中各单性状事件及新表达蛋白质的组合未引发食品和饲料安全或营养问题。预计源自棉花GHB614×LLCotton25×MON 15985的食品和饲料与源自非转基因对照物的食品和饲料具有相同的营养影响。如果有活力的GHB614×LLCotton25×MON 15985棉花种子意外释放到环境中，这种三性状叠加棉花不会引发环境安全问题。上市后环境监测计划和报告间隔符合棉花GHB614×LLCotton25×MON 15985的预期用途。总之，转基因生物小组认为，本申请所述的棉花GHB614×LLCotton25×MON 15985在对人类和动物健康以及环境的潜在影响方面与非转基因对照物一样安全。
