使用[11C]L-蛋氨酸的正电子发射断层扫描对孤立性肺结节进行鉴别诊断。
Differential diagnosis of solitary pulmonary nodules with positron emission tomography using [11C]L-methionine.
作者信息
Kubota K, Matsuzawa T, Fujiwara T, Abe Y, Ito M, Hatazawa J, Ido T, Ishiwata K, Watanuki S
机构信息
Department of Radiology and Nuclear Medicine, Tohoku University, Sendai, Japan.
出版信息
J Comput Assist Tomogr. 1988 Sep-Oct;12(5):794-6. doi: 10.1097/00004728-198809010-00015.
Two patients with solitary pulmonary nodules, 1.5-2.0 cm in diameter, were studied by positron emission tomography using [11C-Methyl]L-methionine (11C-Met). Case 1 showed high accumulation of 11C-Met in the tumor, and a tumor/muscle ratio of 6.0 suggesting malignancy. Tissue obtained by biopsy revealed a squamous cell carcinoma. Case 2 showed nonspecific isotope accumulation in the tumor, and a tumor/muscle ratio of 1.2 suggesting a benign lesion. Lung biopsy demonstrated granuloma. Positron emission tomography with 11C-Met seems to be useful for the differential diagnosis of solitary lung nodules.
两名直径为1.5 - 2.0厘米的孤立性肺结节患者接受了使用[11C - 甲基]L - 蛋氨酸（11C - Met）的正电子发射断层扫描研究。病例1显示肿瘤中11C - Met高度聚集，肿瘤/肌肉比值为6.0，提示为恶性。活检获得的组织显示为鳞状细胞癌。病例2显示肿瘤中同位素非特异性聚集，肿瘤/肌肉比值为1.2，提示为良性病变。肺活检显示为肉芽肿。11C - Met正电子发射断层扫描似乎对孤立性肺结节的鉴别诊断有用。
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