L-[甲基-¹¹C]蛋氨酸在人血浆中的代谢命运。
Metabolic fate of L-[methyl-11C]methionine in human plasma.
作者信息
Ishiwata K, Hatazawa J, Kubota K, Kameyama M, Itoh M, Matsuzawa T, Takahashi T, Iwata R, Ido T
机构信息
Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, Japan.
出版信息
Eur J Nucl Med. 1989;15(10):665-9. doi: 10.1007/BF00251681.
The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumors were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC as at least two components besides methionine, increased with time. Significant individual variations for the metabolism were observed. At 60 min after injection, 36.5% (range: 16%-72%) and 45.3% (range: 13%-74%) of the 11C was measured as methionine and labeled proteins, respectively.
在8例肿瘤患者注射L-[甲基-¹¹C]蛋氨酸后60分钟，对其血浆中的代谢产物进行了测定。在血浆中，经过快速清除后，总放射性保持恒定，而蛋白质结合的放射性迅速增加。通过高效液相色谱法检测到除蛋氨酸外至少还有两种成分的非蛋白质代谢产物随时间增加。观察到代谢存在显著的个体差异。注射后60分钟，分别有36.5%（范围：16%-72%）和45.3%（范围：13%-74%）的¹¹C以蛋氨酸和标记蛋白的形式被检测到。
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