Xishui County People's Hospital Affiliated to Hubei University of Science and Technology, Hubei 530021, China.
Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
Dis Markers. 2020 Jun 12;2020:3787295. doi: 10.1155/2020/3787295. eCollection 2020.
Sestrins (Sesns), a group of oxidative stress-related proteins, have been reported to be involved in various cardiovascular diseases, including aortic dissection and chronic heart failure. This study is aimed at investigating the level of circulating Sesn1, Sesn2, and Sesn3 in hypertension patients.
Plasma levels of Sesn1, Sesn2, and Sesn3 in 400 hypertensive patients and 100 normotensive subjects were detected using enzyme-linked immunosorbent assay (ELISA) kits. The hypertension patients were divided into groups with grade I ( = 140), grade II ( = 180), and grade III ( = 80) hypertension.
Compared with the normotensive subjects, Sesn1, Sesn2, and Sesn3 levels were increased in patients with hypertension, with a gradual increase between the groups with grade I, grade II, and grade III hypertension. Elevated Sesn1, Sesn2, and Sesn3 levels were positively correlated with both the systolic blood pressure (SBP) and diastolic blood pressure (DBP). Moreover, Sesn1, Sesn2, and Sesn3 levels were elevated in patients with dipper hypertension and further increased in patients with nondipper hypertension. In addition, smokers, as well as patients with higher levels of angiotensin II (Ang II) and carotid atherosclerotic plaque (CAP), exhibited increased Sesn1, Sesn2, and Sesn3 levels when compared with patients without these clinical characteristics. Furthermore, plasma levels of Sesn1, Sesn2, and Sesn3 were negatively correlated with the presence of CAP.
Circulating Sesn levels are increased in patients with hypertension and may be a target for the prevention and treatment of clinical hypertension.
Sesn（Sesn）是一组与氧化应激相关的蛋白质，已被报道参与各种心血管疾病，包括主动脉夹层和慢性心力衰竭。本研究旨在研究高血压患者循环 Sesn1、Sesn2 和 Sesn3 的水平。
使用酶联免疫吸附测定（ELISA）试剂盒检测 400 例高血压患者和 100 例血压正常者的血浆 Sesn1、Sesn2 和 Sesn3 水平。将高血压患者分为 I 级（=140）、II 级（=180）和 III 级（=80）高血压组。
与血压正常者相比，高血压患者的 Sesn1、Sesn2 和 Sesn3 水平升高，且 I 级、II 级和 III 级高血压组之间逐渐升高。升高的 Sesn1、Sesn2 和 Sesn3 水平与收缩压（SBP）和舒张压（DBP）均呈正相关。此外，杓型高血压患者 Sesn1、Sesn2 和 Sesn3 水平升高，而非杓型高血压患者进一步升高。此外，与无这些临床特征的患者相比，吸烟者以及血管紧张素 II（Ang II）水平较高和颈动脉粥样硬化斑块（CAP）的患者 Sesn1、Sesn2 和 Sesn3 水平升高。此外，血浆 Sesn1、Sesn2 和 Sesn3 水平与 CAP 的存在呈负相关。
高血压患者循环 Sesn 水平升高，可能是临床高血压预防和治疗的靶点。
