Nold J B, Benjamin S A, Miller G K
Collaborative Radiological Health Laboratory, Colorado State University, Fort Collins 80523.
Radiat Res. 1988 Sep;115(3):472-80.
Immunologic responses were studied in beagle dogs following prenatal (35 days gestation) irradiation to evaluate the effects of ionizing radiation on the developing immune system. Each dog received 1.5 Gy 60Co gamma irradiation or sham irradiation. Prenatally irradiated dogs exhibited a significant reduction in primary humoral antibody responses to inoculated sheep red blood cells, a T-dependent antigen, and a concurrent decrease in T-helper lymphocyte subpopulations in the peripheral blood at 3 to 4 months of age. Similarly, irradiated fetuses have been shown to have defects in epitheliostromal development of the thymus. It is suggested that the postnatal immunologic deficits may relate to the prenatal thymic injury.
为评估电离辐射对发育中免疫系统的影响，对妊娠35天的比格犬进行产前照射后，研究其免疫反应。每只犬接受1.5 Gy的60Coγ射线照射或假照射。产前受照射的犬对接种的绵羊红细胞（一种T细胞依赖性抗原）的初次体液抗体反应显著降低，并且在3至4月龄时外周血中T辅助淋巴细胞亚群同时减少。同样，已显示受照射的胎儿胸腺上皮基质发育存在缺陷。提示出生后的免疫缺陷可能与产前胸腺损伤有关。
