Gupta A, Khanna H D
Indian J Physiol Pharmacol. 1982 Jan-Mar;26(1):54-60.
The immunologic status of the guinea pigs was modified by treatment with antithymocyte serum (ATS): irradiation of gastrointestinal tract lymphoid tissue (GALT) and bone marrow (BM) by gamma-rays. These animals were injected with homologous testes, kidney and heterologous sheep red blood cells respectively in complete Freund's adjuvant. Cell mediate immune response (CMI) and humoral immune response was studied after first, third, fifth and eighth week of allergization. CMI was completely suppressed in guinea pigs treated with ATS, whereas humoral response suppressed to a lesser extent. In GALT and BM irradiated guinea pigs, CMI develops normally. However, marked suppression in the production of antibody titre both against homologous testes, kidney and heterologous sheep red blood cells was observed. Thymic lymphocytes "T' are destroyed by antithymocyte serum which are the mediators of cell mediated immune response. Irradiation of GALT and BM suppresses humoral response thereby supports that these are populated by "B' lymphocytes.
通过抗胸腺细胞血清（ATS）处理、γ射线照射胃肠道淋巴组织（GALT）和骨髓（BM）来改变豚鼠的免疫状态。分别用完全弗氏佐剂给这些动物注射同源睾丸、肾脏和异源绵羊红细胞。在致敏的第一、第三、第五和第八周后研究细胞介导免疫反应（CMI）和体液免疫反应。用ATS处理的豚鼠中CMI被完全抑制，而体液反应受到的抑制程度较小。在GALT和BM照射的豚鼠中，CMI正常发展。然而，观察到针对同源睾丸、肾脏和异源绵羊红细胞的抗体滴度产生明显抑制。胸腺淋巴细胞“T”被抗胸腺细胞血清破坏，而胸腺淋巴细胞是细胞介导免疫反应的介质。GALT和BM的照射抑制体液反应，从而支持这些组织由“B”淋巴细胞构成。
