The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Chinese Medicine Department, E-DA Hospital, Kaohsiung, Taiwan; 1PT Biotechnology Co., Ltd., Taichung, Taiwan.
Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Life Sci. 2020 Sep 15;257:118019. doi: 10.1016/j.lfs.2020.118019. Epub 2020 Jul 3.
Parkinson's disease (PD) is a disease of the human nervous system with an onset, in the sixth and seventh decades of the human life. Chiefly perceived as progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) with the ensued loss of dopamine in the striatum and the presence of Lewy bodies, consisting of α-synuclein agglomeration. In which the neuronal bridge between substantia nigra and striatum plays an advent role in the motor system. Dilapidation of these neurons results in dopamine depletion which in-turn makes hay to PD. Eventually, the etiology and pathogenesis of PD were still on a hike of dilemma. Traditional Chinese medicine (TCM), including Chinese herbal remedies, acupuncture, and manipulative therapies, is commonly used as an adjunctive therapy in different diseases, particularly neurological diseases, in Asian countries. Additionally, TCM might improve the prognoses and the quality of life of patients with PD because it induces less adverse drug reactions. The present review describes research on the various neuroprotective components and herbal extracts from herbal medicines in the context of addressing the effects of PD.
帕金森病（PD）是一种人类神经系统疾病，发病于人类生命的第六和第七个十年。主要表现为黑质致密部（SNpc）中的多巴胺能（DA）神经元进行性退化，随之纹状体中多巴胺丧失和路易体的出现，由α-突触核蛋白聚集组成。其中，黑质和纹状体之间的神经元桥在运动系统中起着重要作用。这些神经元的破坏导致多巴胺耗竭，从而导致 PD。最终，PD 的病因和发病机制仍处于困境之中。在亚洲国家，包括中草药、针灸和推拿疗法在内的传统中医（TCM）通常被用作辅助治疗不同疾病，特别是神经系统疾病。此外，TCM 可能会改善 PD 患者的预后和生活质量，因为它引起的不良反应较少。本综述描述了在解决 PD 影响的背景下，从草药中提取的各种神经保护成分和草药提取物的研究。
