Maury C P, Teppo A M
Fourth Department of Medicine, University of Helsinki, Finland.
Rheumatol Int. 1988;8(3):107-11. doi: 10.1007/BF00272431.
Circulating autoantibodies against amyloid A protein (AA) were demonstrated by enzyme immunoassay in 18/62 patients with rheumatoid arthritis (RA) and in 9/27 patients with systemic lupus erythematosus (SLE). In the subset of RA patients who had developed amyloid, the frequency of antibodies to AA was lower than in those without amyloid (P less than 0.05). The antibody levels showed some variation in serial serum samples during follow-up (1-4 years) of patients with amyloidosis or SLE, but did not correlate with disease activity. In contrast to the patients with rheumatic diseases, patients with inflammatory bowel disease and acute bacterial peritonitis had antibody levels within the range of the healthy control subjects. The results show that autoantibodies to protein AA may occur in rheumatic diseases; their occurrence does not, however, identify subjects with tissue amyloid deposits. Absorption experiments suggest that the antibodies may be directed to circulating amyloid A protein.
通过酶免疫测定法在18/62例类风湿性关节炎（RA）患者和9/27例系统性红斑狼疮（SLE）患者中检测到循环抗淀粉样蛋白A（AA）自身抗体。在已发生淀粉样变的RA患者亚组中，抗AA抗体的频率低于未发生淀粉样变的患者（P<0.05）。在淀粉样变性或SLE患者的随访期（1 - 4年）内，连续血清样本中的抗体水平存在一定变化，但与疾病活动度无关。与风湿性疾病患者不同，炎症性肠病和急性细菌性腹膜炎患者的抗体水平在健康对照受试者范围内。结果表明，抗蛋白AA自身抗体可能出现在风湿性疾病中；然而，它们的出现并不能识别有组织淀粉样沉积物的受试者。吸收实验表明，这些抗体可能针对循环中的淀粉样蛋白A。
