Berstad A, Almodovar K, Weatherstone R G, Hirschowitz B I
Division of Gastroenterology, University of Alabama, Birmingham.
Scand J Gastroenterol. 1988 Aug;23(6):738-42. doi: 10.3109/00365528809093942.
Gastric bleeding from an induced mucosal wound was monitored for 2 h in a rat model in which the normal haemostasis was disturbed mechanically by perfusing the lesion with saline. The bleeding pattern was characterized by continuous and/or rebleeding episodes. Intravenous infusion of platelet-activating factor (PAF) in a dose of 25 ng/kg/min reduced the blood loss by 92% without affecting the bleeding pattern or the macroscopic appearance of the mucosa significantly. Concomitant administration of the PAF receptor antagonist SRI 63-675 in a dose of 50 micrograms/kg/min completely reversed the effects of PAF. The bleeding was unchanged after PAF receptor antagonist alone, suggesting that endogenous PAF might not participate in the in vivo haemostasis after an acute gastric mucosal lesion.
在大鼠模型中，通过向损伤部位灌注生理盐水机械性干扰正常止血过程，对诱导性黏膜伤口的胃出血进行了2小时监测。出血模式的特点是持续出血和/或再次出血发作。以25 ng/kg/分钟的剂量静脉输注血小板活化因子（PAF）可使失血量减少92%，且对出血模式或黏膜的宏观外观无明显影响。同时给予剂量为50微克/千克/分钟的PAF受体拮抗剂SRI 63 - 675可完全逆转PAF的作用。单独给予PAF受体拮抗剂后出血情况未变，这表明内源性PAF可能不参与急性胃黏膜损伤后的体内止血过程。
