Berstad A, Almodovar K, Berstad K, Anderson W, Hirschowitz B I
Division of Gastroenterology, University of Alabama, Birmingham.
Scand J Gastroenterol. 1988 May;23(4):402-6. doi: 10.3109/00365528809093886.
Bleeding from an induced gastric mucosal wound was monitored for 2 h in a rat model, in which normal hemostasis was disturbed mechanically by perfusing the lesion with saline. The hemorrhage was characterized by continuous bleeding and/or episodes of spontaneous rebleeding, as often seen in patients with gastric hemorrhage. The antifibrinolytic agent, tranexamic acid, significantly reduced total bleeding volume and number of rebleeding episodes, suggesting that plasmin-induced fibrinolysis might aggravate gastric mucosal hemorrhage.
在大鼠模型中，通过向损伤部位灌注生理盐水机械性地干扰正常止血过程，对诱导的胃黏膜伤口出血进行了2小时的监测。出血的特征是持续出血和/或自发性再出血发作，这在胃出血患者中很常见。抗纤维蛋白溶解剂氨甲环酸显著降低了总出血量和再出血发作次数，表明纤溶酶诱导的纤维蛋白溶解可能会加重胃黏膜出血。
