Richardson C T, Feldman M
Dept. of Internal Medicine, Veterans Administration Medical Center, Dallas, Texas 75216.
Scand J Gastroenterol. 1988 Aug;23(6):765-8. doi: 10.3109/00365528809093947.
Increased vagal (parasympathetic) stimulation of gastric secretion has been postulated in patients with duodenal ulcer disease. Since salivary secretion is influenced by parasympathetic nerves, we reasoned that duodenal ulcer patients also might have increased salivary secretion. Furthermore, if salivary secretion in duodenal ulcer patients is under nearly maximal parasympathetic stimulation basally, salivary volume might not increase with additional parasympathetic activation induced by sham feeding. To test these hypotheses, we measured basal and sham-feeding-stimulated salivary flow in duodenal ulcer patients and healthy subjects. Contrary to our hypotheses, both basal salivary flow and the salivary response to sham feeding were almost identical in duodenal ulcer patients and healthy subjects. Also, urogastrone concentrations in saliva were approximately the same in duodenal ulcer patients and normal subjects.
十二指肠溃疡病患者被推测存在迷走神经（副交感神经）对胃酸分泌的刺激增加。由于唾液分泌受副交感神经影响，我们推断十二指肠溃疡患者的唾液分泌也可能增加。此外，如果十二指肠溃疡患者的唾液分泌在基础状态下已接近最大副交感神经刺激，那么假饲诱导的额外副交感神经激活可能不会使唾液量增加。为了验证这些假设，我们测量了十二指肠溃疡患者和健康受试者的基础唾液流量以及假饲刺激后的唾液流量。与我们的假设相反，十二指肠溃疡患者和健康受试者的基础唾液流量以及对假饲的唾液反应几乎相同。此外，十二指肠溃疡患者和正常受试者唾液中的尿抑胃素浓度大致相同。
