Nagwani P L, Naik S R, Sachdev S, Srivastava P N, Chuttani H K
Gut. 1979 Jul;20(7):585-9. doi: 10.1136/gut.20.7.585.
Salivary flow rates on mechanical stimulation by forced spitting method and by chemical stimulation with 10% citric acid and gastric acidity using an augmented histamine test were determined in 20 adult patients suffering from duodenal ulcer and in 20 adult control subjects matched with respect to age, sex, and body weight. Salivary flow rates were found to be much higher in response to chemical than to mechanical stimulus in both the groups. Duodenal ulcer patients exhibited an unexplained exaggerated response to chemical stimulation. Salivary pH, amylase, sodium, and potassium levels showed no significant differences between the two groups. The flow rates by either method generally showed a positive correlation with body weight in both the groups. Histamine stimulated gastric acid secretion was higher in duodenal ulcer patients than in controls. Acid secretion did not appear to be related to weight and also showed no consistent correlation with the salivary flow rates. It was concluded that (1) the salivary flow was dependent on body weight in duodenal ulcer patients as well as in controls, and (2) although salivary gland hyperplasia could be postulated in duodenal ulcer patients on the basis of increased salivary flow, the latter was poorly related to maximal acid secretion and therefore, if a combination of parietal cell and salivary gland hyperplasia did exist, it should be considered as incidental.
采用强迫吐痰法进行机械刺激、用10%柠檬酸进行化学刺激以及使用强化组胺试验测定胃酸度，对20例成年十二指肠溃疡患者和20例年龄、性别及体重相匹配的成年对照者的唾液流速进行了测定。结果发现，两组中化学刺激引起的唾液流速均远高于机械刺激引起的唾液流速。十二指肠溃疡患者对化学刺激表现出无法解释的过度反应。两组的唾液pH值、淀粉酶、钠和钾水平均无显著差异。两种方法测得的流速在两组中通常均与体重呈正相关。组胺刺激引起的胃酸分泌在十二指肠溃疡患者中高于对照组。胃酸分泌似乎与体重无关，也与唾液流速无一致的相关性。得出的结论是：(1)十二指肠溃疡患者和对照者的唾液流速均取决于体重；(2)虽然基于唾液流速增加可推测十二指肠溃疡患者存在唾液腺增生，但后者与最大胃酸分泌关系不大，因此，如果确实存在壁细胞和唾液腺增生并存的情况，应将其视为偶然现象。
