Wu S W, Liu X W, Chen Y, Wang X, Zhang W Y
Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Zhonghua Yi Xue Za Zhi. 2020 Jul 7;100(25):1979-1982. doi: 10.3760/cma.j.cn112137-20191213-02720.
To investigate the effect of induction on maternal and neonatal outcomes of vaginal birth after cesarean section (VBAC). Retrospective cohort study. A total of 452 pregnant women who underwent trail of labor after cesarean section (TOLAC) from January 2015 to March 2019 of Beijing Obstetrics and Gynecology Hospital, Capital Medical University were enrolled. According to the mode of the onset of labor, those 331 women who underwent VBAC were divided into spontaneous labor group (280) and induction group(51). According to induction methods, the pregnant women in the induction group was divided into the low-dose oxytocin subgroup (35) and other method subgroup (16, 9 cases with cervical ripening by balloon and 7 cases combined with oxytocin). The effect of induction on labor duration and maternal and neonatal outcome in VBAC were analyzed. No maternal and neonatal death occurred. There were 23.0% (76/331) with forceps, 15.1% (50/331) of postpartum hemorrhage, and 24.5% (81/331) of fetal distress. The gravidity, birth weight and the gestational weeks of delivery in the induction group were significantly higher than those in the spontaneous onset group [2.0 (2.0-3.0) vs 2.0(1.0-2.0) times, 39.0(38.0-40.0) vs 38.0(37.0-39.0) weeks, (3 467±372) vs (3 168±538) g, -3.548,-3.892,-3.813, all 0.01]. The duration of the second stage of labor was significantly longer than that of the spontaneous onset group [43(26-60) vs 30(17-49) min, -2.145,0.05], but the duration of the first stage, the total duration of labor, the rate of forceps, the incidence of postpartum hemorrhage, the rate of perineal incision and the incidence of fetal distress were not obvious different (all 0.05). The duration of the first stage and total duration in oxytocin group were significantly shorter than those other method group [260(210-435) vs 325(250-490) min, 450(355-620) vs 523(370-668) min, -2.001,-1.913, all 0.05]. There were not significantly different in the duration of second stage, mode of delivery, perineal injury, the rate of postpartum hemorrhage, and fetal distress in the two groups (all 0.05). Pregnant women who have undergone TOLAC after caesarean section can be induced after fully evaluation. Although induction prolongs the labor duration, it does not affect the maternal and neonatal complication rate.
探讨引产对剖宫产术后阴道分娩(VBAC)产妇及新生儿结局的影响。回顾性队列研究。选取2015年1月至2019年3月在首都医科大学附属北京妇产医院行剖宫产术后试产(TOLAC)的452例孕妇。根据分娩发动方式,将331例行VBAC的产妇分为自然发动组(280例)和引产组(51例)。根据引产方法,将引产组孕妇分为小剂量缩宫素亚组(35例)和其他方法亚组(16例,其中9例采用球囊促宫颈成熟,7例联合缩宫素)。分析引产对VBAC产程及母婴结局的影响。未发生孕产妇及新生儿死亡。产钳助产率为23.0%(76/331),产后出血率为15.1%(50/331),胎儿窘迫率为24.5%(81/331)。引产组孕妇的孕次、出生体重及孕周显著高于自然发动组[2.0(范围2.0 - 3.0)次 vs 2.0(范围1.0 - 2.0)次,39.0(范围38.0 - 40.0)周 vs 38.0(范围37.0 - 39.0)周,(3467±372)g vs (3168±538)g,P值分别为 - 3.548、 - 3.892、 - 3.813,均P<0.01]。第二产程时间显著长于自然发动组[43(范围26 - 60)分钟 vs 30(范围17 - 49)分钟,P = - 2.145,P<0.05],但第一产程时间、总产程时间、产钳助产率、产后出血发生率、会阴侧切率及胎儿窘迫发生率差异无统计学意义(均P>0.05)。缩宫素组第一产程时间和总产程时间显著短于其他方法组[260(范围210 - 435)分钟 vs 325(范围250 - 490)分钟,450(范围355 - 620)分钟 vs 523(范围370 - 668)分钟,P值分别为 - 2.001、 - 1.913,均P<0.05]。两组第二产程时间、分娩方式、会阴损伤、产后出血率及胎儿窘迫情况差异无统计学意义(均P>开0.05)。剖宫产术后行TOLAC的孕妇经充分评估后可进行引产。虽然引产会延长产程,但不影响母婴并发症发生率。