Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide SA 5000, Australia.
Adelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide SA 5000, Australia.
Nutrients. 2020 Jul 1;12(7):1962. doi: 10.3390/nu12071962.
Glucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intragastric distribution, and subsequent EI in 15 healthy participants and 15 patients with type 2 diabetes (T2D). Participants ingested a 75-g glucose drink on two separate occasions, 30 min after lixisenatide (10 mcg) or placebo subcutaneously, in a randomised, double-blind, crossover design. GE and intragastric distribution were measured for 180 min followed by a buffet-style meal, where EI was quantified. Relationships of EI with total, proximal, and distal stomach content were assessed. In both groups, lixisenatide slowed GE markedly, with increased retention in both the proximal ( < 0.001) and distal ( < 0.001) stomach and decreased EI ( < 0.001). EI was not related to the content of the total or proximal stomach but inversely related to the distal stomach at 180 min in health on placebo ( = -0.58, 0.03) but not in T2D nor after lixisenatide in either group. In healthy and T2D participants, the reduction in EI by lixisenatide is unrelated to changes in GE/intragastric distribution, consistent with a centrally mediated effect.
胰高血糖素样肽-1 受体激动剂可引起体重减轻，这被认为与胃排空（GE）减慢有关。在健康人中，能量摄入（EI）与远端胃的内容物关系更密切，而不是总胃的内容物。我们评估了利西那肽对 15 名健康参与者和 15 名 2 型糖尿病（T2D）患者的 GE、胃内分布以及随后的 EI 的影响。参与者在两次单独的情况下摄入了 75 克葡萄糖饮料，在皮下注射利西那肽（10 mcg）或安慰剂后 30 分钟，以随机、双盲、交叉设计进行。测量了 180 分钟的 GE 和胃内分布，随后进行了自助餐式的膳食，其中量化了 EI。评估了 EI 与总胃、近端胃和远端胃内容物的关系。在两组中，利西那肽均明显减慢了 GE，近端（<0.001）和远端（<0.001）胃中的滞留增加，EI 减少（<0.001）。EI 与总胃或近端胃的内容物无关，但在健康参与者中，在安慰剂下的 180 分钟时与远端胃呈负相关（=-0.58，0.03），但在 T2D 中则没有，也没有在两组中的利西那肽后出现这种相关性。在健康和 T2D 参与者中，利西那肽引起的 EI 减少与 GE/胃内分布的变化无关，这与中枢介导的效应一致。
