Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710049 China.
Department of Applied Chemistry, School of Science, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry, State Key Lab for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an 710049 China.
ACS Appl Mater Interfaces. 2020 Jul 29;12(30):34161-34169. doi: 10.1021/acsami.0c07753. Epub 2020 Jul 16.
Development of a physical barrier with mechanical properties similar to human smooth muscle and an on-demand degradation profile is crucial for the clinical prevention of postoperative adhesion. Herein, a series of supramolecular hydrogels (PMI hydrogels) composed of poly(ethylene glycol) (PEG), methylenediphenyl 4, 4-diisocyanate (MDI), and imidazolidinyl urea (IU, hydrogen bonding reinforced factor) with biodegradability and high toughness are reported to serve as physical barriers for abdominal adhesion prevention. The tensile fracture strength and strain of the PMI hydrogels could be adjusted in the ranges of 0.6-2.3 MPa and 100-440%, respectively, and their Young's moduli (0.2-1.6 MPa) are close to that of human soft tissues like smooth muscle and skin tissue as well as they have outstanding shape memory properties. The PMI hydrogels show good cell and tissue biocompatibility, and the in vivo retention time is in accord with the needs for the postoperative antiadhesion physical barriers. Through an abdominal defect model on mice, this study shows that the PMI hydrogel can completely prevent tissue adhesion compared to the commercialized Seprafilm with high safety. Owing to the promising mechanical properties and good biocompatibility, the PMI hydrogels may be extended for various biomedical applications and the development of advanced flexible electronic devices.
开发具有类似于人类平滑肌机械性能且具有按需降解特性的物理屏障对于临床预防术后粘连至关重要。本文报道了一系列由聚乙二醇（PEG）、二苯甲烷 4,4-二异氰酸酯（MDI）和亚氨基二脲（IU，氢键增强因子）组成的超分子水凝胶（PMI 水凝胶），具有生物降解性和高韧性，可作为预防腹部粘连的物理屏障。PMI 水凝胶的拉伸断裂强度和应变可分别在 0.6-2.3 MPa 和 100-440%的范围内进行调节，其杨氏模量（0.2-1.6 MPa）与人的软组织如平滑肌和皮肤组织相近，且具有出色的形状记忆性能。PMI 水凝胶具有良好的细胞和组织生物相容性，体内留置时间符合术后抗粘连物理屏障的需要。通过在小鼠腹部缺损模型上的研究，本研究表明与商业化的 Seprafilm 相比，PMI 水凝胶具有完全防止组织粘连的效果，且安全性高。由于具有有前景的机械性能和良好的生物相容性，PMI 水凝胶可能会扩展到各种生物医学应用和先进的柔性电子设备的开发。
