Kavelaars A, Ballieux R E, Heijnen C
Department of Pediatric Immunology, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
Brain Behav Immun. 1988 Mar;2(1):57-66. doi: 10.1016/0889-1591(88)90006-2.
In this paper the effect of ACTH 1-24 is described on one of the "early events" occurring during T cell activation: the rise in the concentration of cytosolic free calcium. The increase in cytosolic free calcium induced by concanavalin A or by a monoclonal antibody with specificity for the T cell receptor-T3 complex could be modulated by physiological concentrations of ACTH 1-24. The modulation of the response appeared to be dose dependent. The effect of ACTH 1-24 was maximal at 10(-10) M. No effect of ACTH 1-24 was observed on the basal level of cytosolic free calcium. These results indicate that physiological doses of ACTH can interfere with the responsiveness of T cells to mitogenic and antigenic stimuli.
本文描述了促肾上腺皮质激素1-24（ACTH 1-24）对T细胞激活过程中发生的“早期事件”之一：胞质游离钙浓度升高的影响。伴刀豆球蛋白A或对T细胞受体-T3复合物具有特异性的单克隆抗体诱导的胞质游离钙增加可被生理浓度的ACTH 1-24调节。反应的调节似乎呈剂量依赖性。ACTH 1-24在10^(-10) M时作用最大。未观察到ACTH 1-24对胞质游离钙基础水平有影响。这些结果表明，生理剂量的ACTH可干扰T细胞对有丝分裂原和抗原刺激的反应性。
