Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Nutr Metab Cardiovasc Dis. 2020 Sep 24;30(10):1653-1661. doi: 10.1016/j.numecd.2020.05.026. Epub 2020 Jun 2.
Coffee is known to have a beneficial effect on various liver diseases. The aim of this retrospective longitudinal study was to investigate an association between the amount of coffee consumption and the incidence of fatty liver disease in Korean adults.
Data from a total of 91,436 male and female subjects with the mean follow-up period of 2.8 years were analyzed. The incidence of fatty liver was not associated with the amount of coffee consumption at baseline, but it was associated with the change in the amount of coffee consumption at the follow-up period. Multiple linear regression analyses showed that hazard ratios for incidence of fatty liver disease were significantly low in "increase" group comparing with "no change" group in fully adjusted model. When a subgroup analysis by gender was conducted, similar significant results were observed in male subjects, but not in females.
The increment in the amount of coffee consumption is associated with the lower incidence of fatty liver in Korean men and suggests that increasing the coffee consumption may have a protective effect on fatty liver.
咖啡对各种肝脏疾病均具有有益作用。本回顾性纵向研究旨在调查韩国成年人中咖啡摄入量与脂肪肝疾病发生率之间的关联。
共分析了 91436 名男性和女性受试者的数据，平均随访时间为 2.8 年。基线时咖啡摄入量与脂肪肝的发生率无关联，但与随访期间咖啡摄入量的变化有关。多线性回归分析显示，在完全调整模型中，与“无变化”组相比，“增加”组发生脂肪肝疾病的风险比显著降低。当按性别进行亚组分析时，在男性受试者中观察到类似的显著结果，但在女性中则没有。
咖啡摄入量的增加与韩国男性中脂肪肝的发病率降低相关，提示增加咖啡的摄入量可能对脂肪肝具有保护作用。
