Department of Gastroenterology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
Aliment Pharmacol Ther. 2013 Nov;38(9):1038-44. doi: 10.1111/apt.12489. Epub 2013 Sep 11.
Coffee consumption may modulate the risk of the metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD).
To review the experimental, epidemiological and clinical studies investigating the association between coffee consumption and the risk of MetS and NAFLD.
A literature search was conducted with the aim of finding original experimental, epidemiological and clinical articles on the association between coffee consumption, MetS and NAFLD. The following databases were used: PubMed, Embase, Scopus and Science Direct. We included articles written in English and published up to July 2013.
Three experimental animal studies investigated the effects of coffee in the MetS, whereas five examined whether experimental coffee intake may modulate the risk of fatty liver infiltration. All of the animal studies showed a protective effect of coffee towards the development of MetS and NAFLD. Moreover, we identified eleven epidemiological and clinical studies that met the inclusion criteria. Of them, six were carried out on the risk of the MetS and five on the risk of NAFLD. Four of the six studies reported an inverse association between coffee consumption and the risk of MetS. The two studies showing negative results were from the same study cohort consisting of young persons with a low prevalence of the MetS. All of the epidemiological and clinical studies on NAFLD reported a protective effect of coffee intake.
Coffee intake can reduce the risk of NAFLD. Whether this effect may be mediated by certain components of the MetS deserves further investigation.
咖啡的摄入可能会调节代谢综合征（MetS）和非酒精性脂肪肝（NAFLD）的风险。
综述有关咖啡摄入与 MetS 和 NAFLD 风险之间关系的实验、流行病学和临床研究。
进行了文献检索，旨在寻找关于咖啡摄入、MetS 和 NAFLD 之间关联的原始实验、流行病学和临床文章。使用了以下数据库：PubMed、Embase、Scopus 和 Science Direct。我们纳入了用英文撰写并于 2013 年 7 月前发表的文章。
有三项实验动物研究调查了咖啡对 MetS 的影响，另有五项研究检验了实验性咖啡摄入是否可能调节脂肪肝浸润的风险。所有动物研究均表明咖啡对 MetS 和 NAFLD 的发展具有保护作用。此外，我们还确定了十一项符合纳入标准的流行病学和临床研究。其中，有六项研究是关于 MetS 的风险，五项研究是关于 NAFLD 的风险。六项研究中有四项报告了咖啡摄入与 MetS 风险之间呈负相关。两项报告阴性结果的研究来自同一研究队列，其中包括患有 MetS 低患病率的年轻人。所有关于 NAFLD 的流行病学和临床研究均报告了咖啡摄入具有保护作用。
咖啡摄入可降低 NAFLD 的风险。这种作用是否可能通过 MetS 的某些成分介导，值得进一步研究。
