Schwartzentruber D, Lotze M T, Rosenberg S A
Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892.
Cancer. 1988 Dec 1;62(11):2350-3. doi: 10.1002/1097-0142(19881201)62:11<2350::aid-cncr2820621116>3.0.co;2-s.
The majority (85%) of patients receiving high dose Interleukin-2 (IL-2) experience gastrointestinal side effects, namely nausea, vomiting and diarrhea. In this article we describe four cancer patients that developed localized necrosis or perforation of the colon during IL-2 treatment. They represent 1.3% of patients (n = 315) or 0.9% of treatment courses (n = 452). All underwent surgical intervention and survived to leave the hospital. No common etiologic factor was apparent. Two patients were subsequently retreated with IL-2 without complication. Localized colonic necrosis or perforation is a rare complication associated with high dose IL-2 treatments. Aggressive surgical intervention is advocated and retreatment following recovery is safe.
接受高剂量白细胞介素-2（IL-2）治疗的大多数患者（85%）会出现胃肠道副作用，即恶心、呕吐和腹泻。在本文中，我们描述了4例癌症患者，他们在IL-2治疗期间发生了结肠局部坏死或穿孔。他们占患者总数的1.3%（n = 315）或治疗疗程的0.9%（n = 452）。所有患者均接受了手术干预，且存活出院。未发现明显的共同病因。其中2例患者随后再次接受IL-2治疗，未出现并发症。结肠局部坏死或穿孔是高剂量IL-2治疗相关的罕见并发症。提倡积极的手术干预，康复后再次治疗是安全的。
