“不对称是功能设计的节奏表现，”出自扬·奇肖尔德。
"Asymmetry Is the Rhythmic Expression of Functional Design," a Quotation from Jan Tschichold.
机构信息
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
出版信息
J Bacteriol. 2020 Aug 25;202(18). doi: 10.1128/JB.00370-20.
Abstract
The outer membranes of Gram-negative bacteria provide a permeability barrier to antibiotics and other harmful chemicals. The integrity of this barrier relies on the maintenance of the lipid asymmetry of the outer membrane, and studies of suppressors of a decades-old mutant reveal that YejM plays a key regulatory role and provide a model for the maintenance of this asymmetry.
摘要
革兰氏阴性细菌的外膜为抗生素和其他有害化学物质提供了一个渗透性屏障。这个屏障的完整性依赖于外膜脂质不对称性的维持，对几十年前一个突变体的抑制因子的研究揭示了 YejM 发挥了关键的调节作用，并为维持这种不对称性提供了一个模型。
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