Telsey A M, Merrit T A, Dixon S D
Department of Pediatrics, University of California, San Diego.
Clin Pediatr (Phila). 1988 Nov;27(11):547-50. doi: 10.1177/000992288802701107.
Cocaine use has increased dramatically in the past several years, and multiple medical complications associated with its use have been reported in adults, including bowel infarction and colitis. Maternal use of cocaine during pregnancy has been associated with complications in the fetus and newborn infant, including spontaneous abortions, preterm labor, cerebral infarctions, seizures, renal anomalies, and neurobehavioral and neurophysiologic abnormalities. This paper presents a case of necrotizing enterocolitis at birth in a term newborn exposed to cocaine antenatally. Cultures of the bowel grew two types of Clostridia organisms, Escherichia coli and group B streptococcus. It is suggested that bowel ischemia was secondary to the vasoconstrictive properties of the maternally abused cocaine and that secondary invasion of the bowel by multiple bacteria ensued. This case presents another possible complication to the newborn of maternal cocaine exposure in utero, namely ischemic infarction of the bowel.
在过去几年中，可卡因的使用急剧增加，并且在成年人中已报告了与其使用相关的多种医学并发症，包括肠梗死和结肠炎。孕期母亲使用可卡因与胎儿和新生儿的并发症有关，包括自然流产、早产、脑梗死、癫痫发作、肾脏异常以及神经行为和神经生理异常。本文介绍了一例足月新生儿出生时发生坏死性小肠结肠炎的病例，该新生儿在产前接触过可卡因。肠道培养物中生长出两种梭菌属微生物、大肠杆菌和B组链球菌。提示肠道缺血继发于母亲滥用可卡因的血管收缩特性，随后多种细菌继发侵入肠道。该病例呈现了子宫内母亲接触可卡因给新生儿带来的另一种可能并发症，即肠道缺血性梗死。
