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Controversial: Early Innate Responses to Hepatitis B Virus Infection, an Explanation for Viral Persistence?

作者信息

Broering Ruth, Luo Xufeng, Liu Jia, Lu Mengji

机构信息

Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.

Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

出版信息

Virol Sin. 2021 Feb;36(1):163-166. doi: 10.1007/s12250-020-00235-0. Epub 2020 Jul 6.

DOI:10.1007/s12250-020-00235-0
PMID:32632817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7973328/
Abstract
摘要

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Hepatitis B Virus Particles Activate Toll-Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes.乙型肝炎病毒颗粒最初在感染原代人肝细胞时激活 Toll 样受体 2 信号通路。
Hepatology. 2020 Sep;72(3):829-844. doi: 10.1002/hep.31112. Epub 2020 Jul 11.
2
Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes.乙型肝炎病毒通过人单核细胞中 STAT1 的差异磷酸化诱导炎症和抗病毒信号失衡。
J Immunol. 2019 Apr 15;202(8):2266-2275. doi: 10.4049/jimmunol.1800848. Epub 2019 Mar 6.
3
TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production.
World J Gastroenterol. 2021 Jun 21;27(23):3182-3207. doi: 10.3748/wjg.v27.i23.3182.
TLR2 刺激通过诱导库普弗细胞扩张和产生 IL-10 来增强肝内髓系衍生细胞介导的 T 细胞耐受。
J Immunol. 2018 Apr 1;200(7):2341-2351. doi: 10.4049/jimmunol.1700540. Epub 2018 Feb 19.
4
TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.外周血CD4+ T细胞中TLR2的表达促进Th17反应并与乙型肝炎病毒相关慢加急性肝衰竭的疾病加重相关。
Front Immunol. 2017 Nov 23;8:1609. doi: 10.3389/fimmu.2017.01609. eCollection 2017.
5
Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver.病毒载量影响具有人源化免疫系统和肝脏的小鼠对乙肝病毒的免疫反应。
Gastroenterology. 2017 Dec;153(6):1647-1661.e9. doi: 10.1053/j.gastro.2017.08.034. Epub 2017 Aug 26.
6
Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages.乙型肝炎病毒逃避肝细胞的固有免疫,但激活巨噬细胞产生细胞因子。
Hepatology. 2017 Dec;66(6):1779-1793. doi: 10.1002/hep.29348.
7
Different antiviral effects of IFNα and IFNβ in an HBV mouse model.干扰素α和干扰素β在乙肝病毒小鼠模型中的不同抗病毒作用。
Immunobiology. 2017 Mar;222(3):562-570. doi: 10.1016/j.imbio.2016.11.003. Epub 2016 Nov 8.
8
Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells.高效植入胎儿肝母细胞和同基因免疫细胞的人源化小鼠可发育出人类单核细胞和自然杀伤细胞。
J Hepatol. 2016 Aug;65(2):334-43. doi: 10.1016/j.jhep.2016.04.022. Epub 2016 May 2.
9
Kupffer Cells Support Hepatitis B Virus-Mediated CD8+ T Cell Exhaustion via Hepatitis B Core Antigen-TLR2 Interactions in Mice.库普弗细胞通过乙肝核心抗原与Toll样受体2的相互作用促进小鼠体内乙肝病毒介导的CD8 + T细胞耗竭
J Immunol. 2015 Oct 1;195(7):3100-9. doi: 10.4049/jimmunol.1500839. Epub 2015 Aug 24.
10
Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy.TLR2 及其可溶性形式在慢性乙型肝炎病毒感染中的异常表达和功能障碍及其抗病毒治疗的调节。
Antiviral Res. 2015 Jun;118:10-9. doi: 10.1016/j.antiviral.2015.03.004. Epub 2015 Mar 12.