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Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.中国武汉住院的 2019 年冠状病毒病患者的神经系统表现。
JAMA Neurol. 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127.
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The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.冠状病毒病(COVID-19)疫情的流行病学和发病机制。
J Autoimmun. 2020 May;109:102433. doi: 10.1016/j.jaut.2020.102433. Epub 2020 Feb 26.
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Impacts of the international economic sanctions on Iranian patients with epilepsy.国际经济制裁对伊朗癫痫患者的影响。
Epilepsy Behav. 2019 Jun;95:166-168. doi: 10.1016/j.yebeh.2019.04.011. Epub 2019 May 4.
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How economic sanctions compromise cancer care in Iran.经济制裁如何危及伊朗的癌症治疗。
Lancet Oncol. 2018 Jul;19(7):e334. doi: 10.1016/S1470-2045(18)30427-3. Epub 2018 Jun 29.
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Drug adherence of patients with epilepsy in Iran: the effects of the international economic sanctions.伊朗癫痫患者的药物依从性:国际经济制裁的影响。
Acta Neurol Belg. 2016 Jun;116(2):151-5. doi: 10.1007/s13760-015-0545-6. Epub 2015 Oct 6.
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Reasons for uncontrolled seizures in adults; the impact of pseudointractability.成人癫痫发作失控的原因;假性耐药的影响。
Seizure. 2013 May;22(4):271-4. doi: 10.1016/j.seizure.2013.01.010. Epub 2013 Feb 1.
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Self-perception of seizure precipitants and their relation to anxiety level, depression, and health locus of control in epilepsy.癫痫发作诱发因素的自我认知及其与焦虑水平、抑郁和癫痫患者健康控制点的关系。
Seizure. 2008 Jun;17(4):302-7. doi: 10.1016/j.seizure.2007.09.003. Epub 2007 Oct 31.
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The impact of SARS on epilepsy: the experience of drug withdrawal in epileptic patients.严重急性呼吸综合征对癫痫的影响:癫痫患者停药的经验
Seizure. 2005 Dec;14(8):557-61. doi: 10.1016/j.seizure.2005.08.010. Epub 2005 Sep 26.

COVID-19 大流行对伊朗癫痫患者的影响。

Impacts of the COVID-19 pandemic on Iranian patients with epilepsy.

机构信息

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Neurology, Jefferson Comprehensive Epilepsy Center, Thomas Jefferson University, Philadelphia, PA, USA.

出版信息

Acta Neurol Scand. 2020 Oct;142(4):392-395. doi: 10.1111/ane.13310. Epub 2020 Jul 22.

DOI:10.1111/ane.13310
PMID:32632917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7362008/
Abstract

OBJECTIVE

To investigate the effects of COVID-19 pandemic on patients' perceptions of hardship in obtaining their drugs and if this pandemic and the social restrictions in response to that has resulted in any changes in their seizure control status. We also investigated factors potentially associated with the perceptions of difficulty in obtaining their drugs (eg, polytherapy vs monotherapy, taking imported drugs, and seizure status worsening).

METHODS

We surveyed a random sample of patients with epilepsy, who were registered in our database at Shiraz Epilepsy Center, Iran, on their perceptions on two issues: (a) What has been your experience on obtaining your antiseizure medications in the past 4 weeks (compared to before)? (b) Have you experienced any changes in your seizure control status in the past 4 weeks?

RESULTS

We included 100 patients (53 male and 47 female patients). In response to the question "Have you had any difficulties in the past 4 weeks to obtain your drugs?," 31 people (31%) expressed hardship obtaining their drugs. In response to the question "How has been your seizure control status compared with before?," six people (6%) expressed worsening of their seizure control status in the past 4 weeks. None of the patients reported symptoms of coronavirus infection.

CONCLUSION

About one-third of patients with epilepsy expressed significant hardship obtaining their drugs after the intensification of the COVID-19 outbreak in Iran. The current COVID-19 pandemic could be considered as a major shock to a nation that has already been under significant pressure (ie, Iran).

摘要

目的

研究 COVID-19 大流行对患者获取药物困难程度的影响,以及这种大流行和为应对这种大流行而实施的社会限制是否导致其癫痫发作控制状况发生任何变化。我们还研究了可能与获取药物的困难程度有关的因素(例如,多药治疗与单药治疗、服用进口药物以及癫痫发作状况恶化)。

方法

我们对伊朗设拉子癫痫中心数据库中登记的随机抽取的癫痫患者进行了调查,调查了他们对两个问题的看法:(a)在过去的 4 周内,您在获得抗癫痫药物方面有何经验(与之前相比)?(b)在过去的 4 周内,您的癫痫发作控制状况是否发生了任何变化?

结果

我们共纳入了 100 名患者(53 名男性和 47 名女性患者)。在回答“在过去的 4 周内,您在获得药物方面是否遇到任何困难?”这一问题时,有 31 人(31%)表示在获取药物方面存在困难。在回答“与之前相比,您的癫痫发作控制状况如何?”这一问题时,有 6 人(6%)表示在过去的 4 周内癫痫发作控制状况恶化。没有患者报告出现冠状病毒感染的症状。

结论

大约三分之一的癫痫患者在伊朗 COVID-19 疫情加剧后表示在获取药物方面存在重大困难。目前的 COVID-19 大流行可能被视为一个已经面临巨大压力的国家(即伊朗)的重大冲击。