Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Baotou 014040, China.
Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710049, China.
J Zhejiang Univ Sci B. 2020 Jul;21(7):581-589. doi: 10.1631/jzus.B1900498.
To determine the characteristics of postprandial proximal gastric acid pockets (PPGAPs) and their association with gastroesophageal acid reflux in patients with Barrett's esophagus (BE).
Fifteen patients with BE (defined by columnar lined esophagus of ≥1 cm) and 15 healthy individuals that were matched for age, gender, and body mass index, were recruited. The fasting intragastric pH and the appearance time, length, lowest pH, and mean pH of the PPGAP were determined using a single pH electrode pull-through experiment. For BE patients, a gastroesophageal reflux disease questionnaire (GerdQ) was completed and esophageal 24-h pH monitoring was carried out.
The PPGAP was significantly longer (5 (3, 5) cm vs. 2 (1, 2) cm) and the lowest pH (1.1 (0.8, 1.5) vs. 1.6 (1.4, 1.9)) was significantly lower in patients with short-segment BE than in healthy individuals. The PPGAP started to appear proximally from the gastroesophageal pH step-up point to the esophageal lumen. The acidity of the PPGAP was higher in the distal segment than in the proximal segment. In short-segment BE patients, there were significant correlations between the acidity and the appearance time and length of the PPGAP. The length and acidity of the PPGAP were positively associated with gastroesophageal acid reflux episodes. The acidity of the PPGAP was associated with the DeMeester scores, the GerdQ scores, and the fasting intragastric pH.
In patients with short-segment BE, a PPGAP is commonly seen. Its length and acidity of PPGAP are associated with gastroesophageal acid reflux, the DeMeester score, and the GerdQ score in patients with short-segment BE.
确定巴雷特食管（BE）患者餐后近端胃腔酸袋（PPGAP）的特征及其与胃食管酸反流的关系。
招募了 15 例 BE 患者（定义为≥1cm 的柱状上皮 lined 食管）和 15 例年龄、性别和体重指数匹配的健康对照者。采用单 pH 电极拉过实验测定空腹胃内 pH 及 PPGAP 的出现时间、长度、最低 pH 和平均 pH。对 BE 患者进行胃食管反流病问卷（GerdQ）调查和食管 24 h pH 监测。
与健康对照者相比，短节段 BE 患者的 PPGAP 明显更长（5[3,5]cm 比 2[1,2]cm），最低 pH（1.1[0.8,1.5]比 1.6[1.4,1.9]）更低。PPGAP 从胃食管 pH 升高点起始于食管腔近端。PPGAP 的远端比近端酸度更高。在短节段 BE 患者中，PPGAP 的酸度与出现时间和长度呈显著相关。PPGAP 的长度和酸度与胃食管酸反流事件呈正相关。PPGAP 的酸度与 DeMeester 评分、GerdQ 评分和空腹胃内 pH 值相关。
在短节段 BE 患者中，常可见 PPGAP。其长度和酸度与短节段 BE 患者的胃食管酸反流、DeMeester 评分和 GerdQ 评分相关。
