Department of General and Colorectal Surgery, Poznan University of Medical Sciences, Poznan, Poland.
Department of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland.
J Matern Fetal Neonatal Med. 2022 Jul;35(13):2530-2535. doi: 10.1080/14767058.2020.1786810. Epub 2020 Jul 7.
The objective of this study is to determine a healthy fetal growth pattern of twins from a Polish population based on an outcome-dependent growth curve.
The fetal growth data of live-born twin pregnancies between 25th and 40th week gestation in the period of 1 January 2005 to 31 March 2018 from the database of a tertiary care women's hospital in Western Poland was used to calculate birth weight percentiles. The growth curves of singletons from the same database were used as comparison. Because this study aimed for an outcome-dependent approach for the calculation of fetal growth curves, all babies born that may have high risk of unfavorable outcome were excluded. After application of all exclusion criteria, 1317 records referring to 2634 children were included in our analysis. Growth curves of singletons from the same database were used as reference for this study.
A linear relationship between 10th, 50th, and 90th percentiles and gestational age were found for twins but not for singletons suggesting the different mechanisms of intrauterine growth between singleton and twin pregnancies. Week-to-week weight gain equal to or higher than 150 g in twins also predict a favorable outcome in absence of other pathologies.
The calculated outcome-dependent fetal growth curves for twins in this study may help in the accurate diagnosis of small or large twin fetuses for their gestational age in this Western Poland population.
本研究旨在根据基于结局的生长曲线，确定波兰人群中双胎的健康胎儿生长模式。
本研究使用了 2005 年 1 月 1 日至 2018 年 3 月 31 日期间，来自波兰西部一家三级妇女医院数据库中 25 至 40 孕周活产双胎妊娠的胎儿生长数据来计算出生体重百分位数。使用来自同一数据库的单胎生长曲线作为比较。由于本研究旨在为计算胎儿生长曲线采用基于结局的方法，因此排除了所有可能有不良结局高风险的婴儿。应用所有排除标准后，本研究纳入了 1317 份记录，涉及 2634 名儿童。来自同一数据库的单胎生长曲线被用作本研究的参考。
双胎的 10 百分位、50 百分位和 90 百分位与胎龄之间呈线性关系，但单胎则没有，这表明单胎和双胎妊娠的宫内生长机制不同。双胎每周体重增加等于或高于 150g 也预示着在没有其他病理情况下的良好结局。
本研究为双胎计算的基于结局的胎儿生长曲线，可能有助于在该波兰人群中准确诊断其胎龄的小胎或大胎双胎。
