Primary Health Care Center, University of Montenegro-Faculty of Medicine, Podgorica, Montenegro.
Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):7131-7137. doi: 10.26355/eurrev_202006_21707.
Hypertension is closely related to oxidative stress and inflammation. Endocan is a new inflammation marker whose role is not completely elucidated in hypertension. The aim of this study was to explore the association between endocan and several oxidative stress markers [i.e., advanced oxidation protein products (AOPP), total protein sulfhydryl (SH-) groups and prooxidant-antioxidant balance (PAB)] in adult population with hypertension.
A total of 90 patients with hypertension were compared with 44 controls. Blood pressure, anthropometric and biochemical parameters were measured. Associations of clinical data with hypertension were tested with univariable and multivariable logistic ordinal regression analysis.
Endocan and AOPP were significantly higher in hypertensive patients than in the controls (p=0.006 and p=0.046, respectively). In the multivariable logistic regression analysis, AOPP and endocan kept their independent positive associations with hypertension. As AOPP rose by 1 μmol/L and endocan rose by 1 pg/mL, the probability for hypertension presence rose by 4.2% and 32.2%, respectively and 39.9% of variation in hypertension could be explained with the Model. The area under the Receiver Operating Characteristic curve [(AUC) for AOPP=0.638 (0.550-0.719), p=0.01 and for endocan=0.679 (0.593-0.757), p<0.001] demonstrated sufficient clinical accuracy towards hypertension. On the contrary, the Model showed very good clinical accuracy [AUC= 0.825 (0.749-0.900), p<0.001].
Endocan and AOPP are independently correlated with hypertension in adult population and these tested markers together could be reliable parameters to discriminate patients with hypertension from normotensive ones.
高血压与氧化应激和炎症密切相关。内皮细胞是一种新的炎症标志物，其在高血压中的作用尚未完全阐明。本研究旨在探讨成年高血压患者内皮细胞与几种氧化应激标志物（即先进氧化蛋白产物（AOPP）、总蛋白巯基（SH-）基团和促氧化剂-抗氧化剂平衡（PAB））之间的关系。
将 90 名高血压患者与 44 名对照进行比较。测量血压、人体测量和生化参数。使用单变量和多变量逻辑有序回归分析测试临床数据与高血压的相关性。
高血压患者的内皮细胞和 AOPP 明显高于对照组（p=0.006 和 p=0.046）。在多变量逻辑回归分析中，AOPP 和内皮细胞与高血压保持独立的正相关关系。当 AOPP 增加 1 μmol/L 和内皮细胞增加 1 pg/mL 时，高血压的可能性分别增加 4.2%和 32.2%，模型可以解释高血压变化的 39.9%。受试者工作特征曲线下面积（AUC）（AOPP=0.638（0.550-0.719），p=0.01 和 endocan=0.679（0.593-0.757），p<0.001）表明对高血压具有足够的临床准确性。相反，该模型表现出非常好的临床准确性[AUC=0.825（0.749-0.900），p<0.001]。
内皮细胞和 AOPP 与成年人群中的高血压独立相关，这些测试标志物结合起来可以作为区分高血压患者和正常血压患者的可靠参数。
