Tanakol Ali, Oba Muazzez Cigdem, Uzuncakmak Tugba Kevser, Askin Ozge, Kutlubay Zekayi
Cerrahpasa Medical Faculty, Department of Dermatology and Venereology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Department of Dermatology and Venereology, Diyarbakir Selahaddin Eyyubi State Hospital, Diyarbakir, Turkey.
Dermatol Ther. 2020 Nov;33(6):e13978. doi: 10.1111/dth.13978. Epub 2020 Aug 6.
Various laser therapies have been used for the treatment of alopecia areata (AA). Enhanced hair regrowth was reported with the use of ablative fractional 2940-nm erbium:yttrium-aluminum-garnet (Er:YAG) laser in a murine model. However, clinical effectiveness of fractional Er:YAG laser for hair disorders has not been investigated in human studies. The aim of our study was to assess the effectiveness of 2940-nm fractional Er:YAG laser in the treatment of chronic AA that is unresponsive to conventional therapies. Twenty-five AA patients underwent three sessions, each 4 to 6 weeks apart, of fractional Er:YAG laser. Clinical evaluation was done at baseline and 1 month post-treatment (follow-up) by photographic assessment. Subjective evaluation by patient satisfaction score was also performed. Photographic evaluation of the patients revealed a mean percent change in SALT score of 17.4 ± 3.5% at follow-up. A total of 16 patients who were treated for patchy AA of the scalp showed 27.8 ± 31.3% regrowth. Five patients who were treated for AA of the beard had 39 ± 34.2% regrowth. Fractional Er:YAG laser might be a therapeutic alternative for patients with patchy AA of the scalp and beard that is unresponsive to conventional therapies.
多种激光疗法已被用于斑秃（AA）的治疗。在小鼠模型中，使用剥脱性分数2940纳米铒：钇铝石榴石（Er:YAG）激光可促进毛发生长。然而，分数Er:YAG激光治疗毛发疾病的临床有效性尚未在人体研究中得到探究。我们研究的目的是评估2940纳米分数Er:YAG激光治疗对传统疗法无反应的慢性斑秃的有效性。25名斑秃患者接受了三次分数Er:YAG激光治疗，每次治疗间隔4至6周。在基线和治疗后1个月（随访）通过照片评估进行临床评估。还通过患者满意度评分进行主观评估。对患者的照片评估显示，随访时SALT评分的平均变化百分比为17.4±3.5%。总共16名接受头皮斑片状斑秃治疗的患者毛发再生率为27.8±31.3%。5名接受胡须斑秃治疗的患者毛发再生率为39±34.2%。分数Er:YAG激光可能是对传统疗法无反应的头皮和胡须斑片状斑秃患者的一种治疗选择。
