Laboratorio di Immunoreumatologia e rigenerazione tissutale, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.
Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum-University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Int J Mol Sci. 2020 Feb 16;21(4):1328. doi: 10.3390/ijms21041328.
Platelet concentrates (PCs), mostly represented by platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biological blood-derived products that may combine plasma/platelet-derived bioactive components, together with fibrin-forming protein able to create a natural three-dimensional scaffold. These types of products are safely used in clinical applications due to the autologous-derived source and the minimally invasive application procedure. In this narrative review, we focus on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculoskeletal medicine, efficacy and main limits of the different studies.
血小板浓缩物（PCs），主要包括富血小板血浆（PRP）和富血小板纤维蛋白（PRF），是自体生物源性血液衍生产品，可结合血浆/血小板衍生的生物活性成分，以及能够形成天然三维支架的纤维蛋白形成蛋白。由于其源自自体和微创应用程序，这些类型的产品可安全地用于临床应用。在这篇叙述性综述中，我们重点关注了三种与使用血小板浓缩物治疗肌肉骨骼疾病有关的主要问题：（a）制备 PCs 的不同程序，（b）与所采用的方法学程序类型相关的 PCs 组成，以及（c）在肌肉骨骼医学中的临床应用、不同研究的疗效和主要限制。
