Tachi J, Amino N, Iwatani Y, Tamaki H, Mori M, Aozasa M, Tanizawa O, Miyai K
Department of Laboratory Medicine, Osaka University Medical School, Japan.
J Clin Endocrinol Metab. 1988 Nov;67(5):1049-53. doi: 10.1210/jcem-67-5-1049.
Serum antidouble stranded DNA antibody levels were measured during pregnancy and after delivery in women who had postpartum exacerbations of Graves' and Hashimoto's diseases. The changes in serum anti-DNA antibody levels closely paralleled those in the serum free T4 index, significantly increasing in the thyrotoxic phase 3-8 months postpartum in women with postpartum exacerbations of thyrotoxicosis due to Graves' disease and 1-3 months postpartum in women with postpartum destructive thyrotoxicosis of Graves' and Hashimoto's diseases. No change in anti-DNA antibody level was found in women with no postpartum exacerbations of thyroid diseases, nor could we demonstrate significant increases in serum anti-DNA antibody titers in patients with thyrotoxicosis due to subacute thyroiditis or in normal pregnant and postpartum women. The changes in serum anti-DNA antibody titers may reflect some generalized immunological abnormality in women who have postpartum exacerbations of Graves' or Hashimoto's diseases.
对患有格雷夫斯病和桥本氏病产后病情加重的女性，在孕期及产后测定其血清抗双链DNA抗体水平。血清抗DNA抗体水平的变化与血清游离T4指数的变化密切平行，在因格雷夫斯病导致产后甲状腺毒症病情加重的女性中，产后3 - 8个月甲状腺毒症期显著升高，在患有格雷夫斯病和桥本氏病产后破坏性甲状腺毒症的女性中，产后1 - 3个月显著升高。甲状腺疾病无产后病情加重的女性，其抗DNA抗体水平无变化，我们也未证明亚急性甲状腺炎所致甲状腺毒症患者或正常妊娠及产后女性血清抗DNA抗体滴度有显著升高。血清抗DNA抗体滴度的变化可能反映了患有格雷夫斯病或桥本氏病产后病情加重女性的一些全身性免疫异常。
