China Three Gorges University, RenHe Hospital, Yichang, China.
Department of Biochemistry, China Three Gorges University, Yichang, China.
Curr Pharm Des. 2021;27(1):91-104. doi: 10.2174/1381612826666200707130246.
Osteoporosis (OP) is the most common bone disease, which is listed by the World Health Organization (WHO) as the third major threat to life and health among the elderly. The etiology of OP is multifactorial, and its potential regulatory mechanism remains unclear. Long non-coding RNAs (LncRNAs) are the non-coding RNAs that are over 200 bases in the chain length. Increasing evidence indicates that LncRNAs are the important regulators of osteogenic and adipogenic differentiation, and the occurrence of OP is greatly related to the dysregulation of the bone marrow mesenchymal stem cells (BMSCs) differentiation lineage. Meanwhile, LncRNAs affect the occurrence and development of OP by regulating OP-related biological processes.
In the review, we summarized and analyzed the latest findings of LncRNAs in the pathogenesis, diagnosis and related biological processes of OP. Relevant studies published in the last five years were retrieved and selected from the PubMed database using the keywords of LncRNA and OP.
RESULTS/CONCLUSION: The present study aimed to examine the underlying mechanisms and biological roles of LncRNAs in OP, as well as osteogenic and adipogenic differentiation. Our results contributed to providing new clues for the epigenetic regulation of OP, making LncRNAs the new targets for OP therapy.
骨质疏松症（OP）是最常见的骨骼疾病，被世界卫生组织（WHO）列为老年人生命健康的第三大威胁。OP 的病因是多因素的，其潜在的调节机制尚不清楚。长链非编码 RNA（LncRNA）是链长超过 200 个碱基的非编码 RNA。越来越多的证据表明，LncRNAs 是成骨和成脂分化的重要调节因子，OP 的发生与骨髓间充质干细胞（BMSCs）分化谱系的失调密切相关。同时，LncRNAs 通过调节与 OP 相关的生物学过程来影响 OP 的发生和发展。
在综述中，我们总结和分析了 LncRNA 在 OP 的发病机制、诊断及相关生物学过程中的最新发现。使用 LncRNA 和 OP 等关键词从 PubMed 数据库中检索并选择了过去五年发表的相关研究。
结果/结论：本研究旨在探讨 LncRNAs 在 OP 以及成骨和成脂分化中的潜在机制和生物学作用。我们的研究结果为 OP 的表观遗传调控提供了新的线索，使 LncRNAs 成为 OP 治疗的新靶点。
