Faculty of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology, Pasteur Institute, Tehran, Iran.
Infect Disord Drug Targets. 2020;20(6):920-924. doi: 10.2174/1871526520666200707113955.
Helicobacter pylori is a slow-growing micro-aerophilic gram-negative organism found in the stomach and duodenum. It is also associated with a number of stomach-duodenal diseases.
There are invasive and non-invasive methods to detect Helicobacter pylori infections. In a 13-months period, 101 patients with clinical signs of infection confirmed by biopsy and Rapid Urease test as well as a culture were included in this study.
There were significant correlations between breath urease test, anti-Helicobacter pylori serum IgG and IgA as well as fecal Helicobacter pylori Ag with the gold-standard method, (P=0.001) Moreover, there was a significant correlation between Monocytosis (P= 0.05) and goldstandard method.
Based on studies conducted on patients with Helicobacter pylori infection, noninvasive diagnostics methods can be useful in the diagnosis of Helicobacter infections rather than evaluating anti-Helicobacter pylori serum IgM and also increased blood monocytes could be a reliable confirmation for detection. Furthermore, Monocytosis must be considered as a Helicobacter pylori infection at the first step in an area with a high infected percentage.
幽门螺杆菌是一种生长缓慢的微需氧革兰氏阴性菌，存在于胃和十二指肠中。它还与许多胃十二指肠疾病有关。
有侵袭性和非侵袭性方法来检测幽门螺杆菌感染。在 13 个月的时间里，我们纳入了 101 名经活检和快速尿素酶试验以及培养证实有感染临床症状的患者进行这项研究。
呼气尿素酶试验、抗幽门螺杆菌血清 IgG 和 IgA 以及粪便幽门螺杆菌 Ag 与金标准方法之间存在显著相关性（P=0.001）。单核细胞增多症（P=0.05）与金标准方法之间也存在显著相关性。
基于对幽门螺杆菌感染患者的研究，非侵入性诊断方法可用于诊断幽门螺杆菌感染，而不是评估抗幽门螺杆菌血清 IgM，并且外周血单核细胞增多症可能是检测的可靠确认指标。此外，在感染率较高的地区，单核细胞增多症必须被视为幽门螺杆菌感染的第一步。
