Ghaeini-Hesaroeiye Sobhan, Razmi Bagtash Hossein, Boddohi Soheil, Vasheghani-Farahani Ebrahim, Jabbari Esmaiel
Biomedical Engineering Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran 14115, Iran.
Biomimetic Materials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, SC 29208, USA.
Gels. 2020 Jul 4;6(3):20. doi: 10.3390/gels6030020.
Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release.
纳米凝胶，即纳米结构水凝胶，是生物医学工程中最具吸引力的材料之一。纳米凝胶广泛应用于医学领域，如癌症治疗、蛋白质、基因和DNA的靶向递送以及组织再生中的支架。纳米凝胶的一个显著特点是其对外部刺激具有可调谐响应性。在本综述中，将讨论热敏纳米凝胶，重点关注其化学结构中负责热敏性的部分。这些热敏部分可分为四类，即带有酰胺基团的聚合物、醚基团、乙烯基醚基团以及带有疏水基团的亲水性聚合物。这些新型热响应纳米凝胶为许多临床应用中的患者治疗提供了有效的药物递送系统和组织再生构建体，如靶向、持续和控释。
