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白术和五味子提取物可改善咳嗽和增加咳痰。

Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm.

机构信息

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.

Department of Botanical Drug, Chong Kun Dang (CKD) Pharm Research Institute, Yongin-si, Gyeonggi-do 16995, Korea.

出版信息

Molecules. 2020 Jul 4;25(13):3064. doi: 10.3390/molecules25133064.

DOI:10.3390/molecules25133064
PMID:32635583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7411911/
Abstract

Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic obstructive pulmonary diseases. To relieve these symptoms and diseases, various ingredients are being used despite the debates on their clinical efficacy. We aimed to investigate the effects of the extract CKD-497, composed of Atractylodis Rhizoma Alba and Fructus Schisandrae, in relieving cough and facilitating expectoration of phlegm. CKD-497 was found to inhibit inflammatory mediators such as interleukin-8 (IL-8) and tumor necrosis factor α (TNF-α) in lipopolysaccharide (LPS)-treated mouse macrophages and transient receptor potential cation channel 1 (TRPV-1)-overexpressed human bronchial epithelial cells stimulated by capsaicin. CKD-497 decreased the viscosity of the mucin solution. During in vivo experiments, CKD-497 reduced coughing numbers and increased expectoration of phlegm via mucociliary clearance enhancement. Collectively, these data suggest that CKD-497 possesses potential for cough and phlegm expectoration treatment.

摘要

咳嗽和咳痰在呼吸道疾病中经常发生，如上呼吸道感染、急性支气管炎和慢性阻塞性肺疾病。为了缓解这些症状和疾病，尽管对其临床疗效存在争议，但仍在使用各种成分。我们旨在研究由白术和五味子组成的提取物 CKD-497 对缓解咳嗽和促进排痰的作用。研究发现，CKD-497 可抑制脂多糖（LPS）处理的小鼠巨噬细胞中的炎症介质，如白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α），以及辣椒素刺激的过表达瞬时受体电位阳离子通道 1（TRPV-1）的人支气管上皮细胞。CKD-497 降低了粘蛋白溶液的粘度。在体内实验中，CKD-497 通过增强黏液纤毛清除作用，减少咳嗽次数并增加痰液排出。总之，这些数据表明 CKD-497 具有治疗咳嗽和咳痰的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/30d868589757/molecules-25-03064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/1e63a3054e15/molecules-25-03064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/e617b70d9c06/molecules-25-03064-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/50e2955977cb/molecules-25-03064-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/460f6a11cf5a/molecules-25-03064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/9858f17b46f1/molecules-25-03064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/30d868589757/molecules-25-03064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/1e63a3054e15/molecules-25-03064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/e617b70d9c06/molecules-25-03064-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/50e2955977cb/molecules-25-03064-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/460f6a11cf5a/molecules-25-03064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/9858f17b46f1/molecules-25-03064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a28b/7411911/30d868589757/molecules-25-03064-g006.jpg

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